Objectively Assessed Physical Activity, Sedentary Time, and Coronary Artery Calcification in Healthy Older Adults
Objectively Assessed Physical Activity, Sedentary Time, and Coronary Artery Calcification in Healthy Older Adults
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DOI：
10.1161/atvbaha.111.236877
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发表时间：
2012-02-01
影响因子：
8.7
通讯作者：
Steptoe, Andrew
中科院分区：
文献类型：
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作者：
Hamer, Mark;Venuraju, Shreenidhi M.;Steptoe, Andrew
目的——体力活动与降低心血管疾病风险有关，但与冠状动脉病变相关的数据一直相互矛盾。这些不一致可能部分是由于对身体活动的不可靠评估以及自我报告数据所施加的限制造成的。本研究的目的是确定客观测量的身体活动与冠状动脉钙 (CAC) 之间的关系。 方法和结果 - 参与者是 443 名健康男性和女性（平均年龄 = 66 +/- 6 岁），没有冠心病病史或客观体征，来自 Whitehall II 流行病学队列。使用连续 7 天在清醒时间佩戴的加速度计客观测量体力活动（平均每日佩戴时间 = 889 +/- 68 分钟/天）。使用电子束计算机断层扫描测量每个参与者的 CAC，并根据 Agatston 评分系统进行量化。平均而言，54.4% 的样本记录了每天至少 30 分钟的中度至剧烈体力活动 (MVPA)。 MVPA 与可检测到的 CAC 之间没有关联。对于可检测到 CAC 的参与者 (n = 283)，观察到 MVPA（分钟/天）和 Log Agatston 评分之间存在微弱的负相关关系（B = -0.008，95% CI：-0.16 至 0.00，P = 0.05），尽管在调整年龄、性别和传统风险因素后，这种关联不再存在。没有发现轻度活动或久坐时间之间存在关联。结论 - 我们的结果证实客观评估的体力活动与 CAC 之间没有关联。由于 CAC 测量无法识别更脆弱的病变，因此需要进行更多研究来检验体力活动是否可以促进斑块稳定性。 （动脉硬化血栓 Vasc Biol.2012；32：500-505。）
Objective-Physical activity is related to lower risk of cardiovascular disease, but data relating to coronary lesions have been conflicting. These inconsistencies may in part be due to unreliable assessment of physical activity and limitations imposed by self-reported data. The purpose of this study was to determine the relationship between objectively measured physical activity and coronary artery calcium (CAC).Methods and Results-Participants were 443 healthy men and women (mean age = 66 +/- 6 years), without history or objective signs of coronary heart disease, drawn from the Whitehall II epidemiological cohort. Physical activity was objectively measured using accelerometers worn during waking hours for 7 consecutive days (average daily wear time = 889 +/- 68 minutes/day). CAC was measured in each participant using electron beam computed tomography and was quantified according to the Agatston scoring system. On average, 54.4% of the sample recorded at least 30 minutes/day of moderate to vigorous physical activity (MVPA). There was no association between MVPA and presence of detectable CAC. For the participants with detectable CAC (n = 283) a weak inverse relationship between MVPA (minutes/day) and log Agatston score was observed (B = -0.008, 95% CI: -0.16 to 0.00, P = 0.05), although the association was no longer present after adjustments for age, sex, and conventional risk factors. No associations were seen for light activity or sedentary time.Conclusion-Our results confirm no association between objectively assessed physical activity and CAC. Because CAC measures cannot identify more vulnerable lesions, additional studies are required to examine whether physical activity can promote plaque stability. (Arterioscler Thromb Vasc Biol. 2012;32:500-505.)