Effects of ACE2 deficiency on physical performance and physiological adaptations of cardiac and skeletal muscle to exercise
Effects of ACE2 deficiency on physical performance and physiological adaptations of cardiac and skeletal muscle to exercise
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DOI：
10.1038/hr.2016.28
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发表时间：
2016-07-01
影响因子：
5.4
通讯作者：
Bader, Michael
中科院分区：
文献类型：
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作者：
Motta-Santos, Daisy;Souza dos Santos, Robson Augusto;Bader, Michael
肾素-血管紧张素系统（RAS）与运动引起的生理适应有关。血管紧张素转换酶（ACE）2是组织中RAS的主要调节剂，因为它将血管紧张素（Ang）II代谢为Ang-（1-7）。本研究的目的是确定ACE 2缺乏对自愿运行引起的体能和生理适应的影响。在ACE 2缺陷型（ACE 2（-/y））和野生型（ACE 2（+/y））小鼠中评估了体能、身体成分和血浆血管紧张素水平，以及左心室（LV）和骨骼肌（腓肠肌）中RAS成分的组织形态和基因表达。自愿车轮跑6周后。ACE 2（-/y）小鼠比ACE 2（+/y）小鼠跑得少（19 +/- 4.7 vs. 26 +/- 12.6转/天x100，P
The renin-angiotensin system (RAS) is related to physiological adaptations induced by exercise. Angiotensin-converting enzyme (ACE) 2 is a major regulator of the RAS in tissues, as it metabolizes angiotensin (Ang) II to Ang-(1-7). The aim of this study was to determine the effects of ACE2 deficiency on physical performance and physiological adaptations induced by voluntary running. Physical performance, body composition and plasma angiotensin levels, as well as tissue morphology and gene expression of RAS components in the left ventricle (LV) and skeletal muscle (gastrocnemius), were evaluated in ACE2-deficient (ACE2(-/y)) and wild-type (ACE2(+/y)) mice after 6 weeks of voluntary wheel running. ACE2(-/y) mice run less than ACE2(+/y) mice (19 +/- 4.7 vs. 26 +/- 12.6 revolutions per day x 100, P