Usefulness of optimized gadolinium-enhanced fast fluid-attenuated inversion recovery MR imaging in revealing lesions of the brain.
Usefulness of optimized gadolinium-enhanced fast fluid-attenuated inversion recovery MR imaging in revealing lesions of the brain.
复制标题
优化的钆增强快速流体衰减反转恢复磁共振成像在揭示大脑病变中的有用性。
DOI：
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复制
发表时间：
1998
期刊：
影响因子：
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通讯作者：
R. E. Walker
中科院分区：
文献类型：
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作者：
E. Melhem;R. Bert;R. E. Walker
目的
本研究的目的是比较对比增强的钆增强优化快速液体衰减反转恢复（FLAIR）MR成像与钆增强优化T1加权自旋回波MR成像显示的脑病变的对比增强。
受试者和方法
使用计算机模拟，我们优化了快速FLAIR参数（TR，TEeff和反转时间）和T1加权自旋回波参数（TR和TE），以提供大脑和白色物质增强病变之间的最大信号强度差异。76名连续患者接受了两种优化技术的脑部单剂量钆增强MR成像，这两种技术在空间分辨率、带宽和激发次数方面都是匹配的。由两名观察者独立评估钆增强快速FLAIR和T加权自旋回波MR图像的增强病变的数量和大小以及灰白质分化的程度。使用增强病灶和正常白色物质中的8 x 8像素感兴趣区域测量直径大于或等于1.0 cm的增强病灶的对比度噪声比。
结果
快速FLAIR MR成像最具揭示性的参数被证明是TR为1500 msec，反转时间为683 msec，TEeff为16 msec。对于T1加权自旋回波MR成像，优化参数为TR为550 msec，TE为16 msec。在28例患者中，我们看到了至少一种MR成像技术的脑增强病变。T1加权自旋回波序列（n = 141）比快速FLAIR序列（n = 94）显示更多的病变（p <0.03）。快速FLAIR序列的灰白质分化明显更好（p <0.001）。T1加权自旋回波序列增强病灶的对比噪声比更大（p <0.001）。
结论
在这项研究中，优化的钆增强常规T1加权自旋回波MR成像被证明在显示脑部病变方面优于钆增强快速FLAIR MR成像上级。
OBJECTIVE
The purpose of this study was to compare the contrast enhancement of lesions of the brain revealed by gadolinium-enhanced optimized fast fluid-attenuated inversion recovery (FLAIR) MR imaging with that of lesions on gadolinium-enhanced optimized T1-weighted spin-echo MR imaging.
SUBJECTS AND METHODS
Using computer simulations, we optimized the fast FLAIR parameters (TR, TEeff, and inversion time) and the T1-weighted spin-echo parameters (TR and TE) to provide maximum difference in signal intensity between enhancing lesions of the brain and white matter. Seventy-six consecutive patients referred for single-dose gadolinium-enhanced MR imaging of the brain underwent both optimized techniques, which were matched for spatial resolution, bandwidth, and number of excitations. The gadolinium-enhanced fast FLAIR and T -weighted spin-echo MR images were evaluated independently by two observers for number and size of enhancing lesions and for the degree of gray-white matter differentiation. Contrast-to-noise ratios were measured for enhancing lesions 1.0 cm or larger in diameter using 8 x 8 pixel regions of interest in the enhancing lesions and normal white matter.
RESULTS
The most revealing parameters for fast FLAIR MR imaging proved to be a TR of 1500 msec, an inversion time of 683 msec, and a TEeff of 16 msec. For T1-weighted spin-echo MR imaging, the optimized parameters were a TR of 550 msec and a TE of 16 msec. In 28 patients, we saw enhancing lesions of the brain with at least one MR imaging technique. More lesions were seen on the T1-weighted spin-echo sequence (n = 141) than on the fast FLAIR sequence (n = 94) (p < .03). Gray-white matter differentiation was significantly better on the fast FLAIR sequence (p < .001). Contrast-to-noise ratios of enhancing lesions were greater on the T1-weighted spin-echo sequence (p < .001).
CONCLUSION
In this study, optimized gadolinium-enhanced conventional T1-weighted spin-echo MR imaging proved superior to gadolinium-enhanced fast FLAIR MR imaging in revealing lesions of the brain.
影响因子：
19.7
作者：
RYDBERG, JN;HAMMOND, CA;RIEDERER, SJ
通讯作者：
RIEDERER, SJ