Retrograde neural circuit specification by target-derived neurotrophins and growth factors.
Retrograde neural circuit specification by target-derived neurotrophins and growth factors.
复制标题
DOI：
10.1016/j.conb.2010.07.007
复制
发表时间：
2011-02
影响因子：
5.7
通讯作者：
Wang F
中科院分区：
文献类型：
--
作者：
da Silva S;Wang F
发育过程中的神经回路组装涉及一系列高度调节的步骤。虽然遗传预先确定的程序在早期步骤中发挥关键作用，包括神经发生，迁移和轴突的初始生长和引导;越来越多的证据表明，随着轴突到达其靶点，神经元分化和连接形成的后期步骤可能会受到靶源信号的影响甚至指定。在这里，我们试图提供一个简短的综合审查逆行神经营养因子和生长因子信号在调节神经回路特异性的最后阶段，如轴突投射，树突状图案，神经递质表型收购，和突触形成的作用。
Neural circuit assembly during development involves a series of highly regulated steps. While genetically pre-determined programs play key roles in the early steps including neurogenesis, migration, and initial growth and guidance of axons; increasing evidence indicates that as the axons reach their targets, the late steps of neuronal differentiation and connectivity formation may be influenced or even specified by target-derived signals. Here we attempt to provide a brief synthesized review on the roles of retrograde neurotrophin and growth factor signaling in regulating the final stages of neural circuit specificity such as axonal projection, dendritic patterning, neurotransmitter phenotype acquisition, and synapse formation.