Human infection with Ascaris lumbricoides is associated with a polarized cytokine response
Human infection with Ascaris lumbricoides is associated with a polarized cytokine response
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DOI：
10.1086/315830
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发表时间：
2000-10-01
影响因子：
6.4
通讯作者：
Nutman, TB
中科院分区：
文献类型：
--
作者：
Cooper, PJ;Chico, ME;Nutman, TB
为了定义对蛔虫感染的细胞因子反应，将中等感染强度的年轻人 (n = 73) 对成虫和幼虫阶段蛔虫抗原的细胞免疫反应与一组未感染的对照受试者 (n = 40) 进行了比较。与未感染的对照受试者相比，被蚓螈感染的受试者对成虫和幼虫阶段抗原具有显着更强的淋巴增殖反应（P < .01）。在感染组中，寄生虫抗原刺激的外周血单核细胞 (PBMC) 表达白细胞介素 (IL)-4 和 IL-5 的频率显着较高 (P < .001)，而在研究的 2 组中，表达 IL-10 和干扰素 γ 的 PBMC 的频率相似。与未感染受试者相比，感染组中 Th2 与 Th1 细胞因子频率的比率显着升高，成人 (P < .05) 和 L3/L4 阶段 (P < .001) 抗原刺激的 PBMC 产生的 IL-5 蛋白也显着升高。对这些数据的分析表明，流行地区的蚓螈感染与高度极化的 2 型细胞因子反应相关。
To define the cytokine response to Ascaris lumbricoides infection, the cellular immune response to adult and larval-stage Ascaris antigens in young adults with moderate infection intensities (n = 73) was compared with that of a group of uninfected control subjects (n = 40). A. lumbricoides-infected subjects had significantly greater lymphoproliferative responses to adult and larval-stage antigens, compared with uninfected control subjects (P < .01). The frequencies of parasite antigen-stimulated peripheral blood mononuclear cell (PBMC)-expressing interleukin (IL)-4 and IL-5 were significantly greater in the infected group (P < .001), whereas the frequencies of IL-10- and interferon-gamma-expressing PBMC were similar in the 2 groups studied. The ratios of Th2 to Th1 cytokine frequencies were significantly elevated in the infected group, compared with those in uninfected subjects, as was IL-5 protein production by PBMC stimulated with adult (P < .05) and L3/L4 stage (P < .001) antigens, Analysis of these data indicates that A. lumbricoides infections in endemic regions are associated with a highly polarized type 2 cytokine response.