Controlled expansion of peripheral nerves: comparison of nerve grafting and nerve expansion/repair for canine sciatic nerve defects.
Controlled expansion of peripheral nerves: comparison of nerve grafting and nerve expansion/repair for canine sciatic nerve defects.
复制标题
周围神经的控制扩张：神经移植和神经扩张/修复犬坐骨神经缺损的比较。
DOI：
10.1097/00005373-199007000-00093
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
M. Bubrick
中科院分区：
文献类型：
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作者：
R. Wood;M. H. Adson;A. Vanbeek;G. Peltier;M. M. Zubkoff;M. Bubrick
神经移植的固有缺陷使得寻找替代技术治疗节段性神经丢失是必要的。本研究在动物模型上比较了神经移植和神经扩张/修复技术在处理节段性神经损伤中的作用。8只犬造成双侧节段性坐骨神经缺损。一侧切除2厘米长的神经段，代之以神经移植物；另一侧结扎造成2厘米长的缺损区，神经进行初步扩张，然后修复。18个月后，测定7只存活动物的神经传导速度(NCV)、腓肠肌收缩力(GCF)和肌重(GMW)。NCV分别为58.66+/-34.18m/s和47.73+/-7.93g(p=0.40)，GCF值分别为619.04+/-353.70 gm和726.80+/-415.78 gm(p=0.2)，GMW分别为82.80+/-5.68g和109.55+/-20.63g(p=0.02)。结果提示：1)传统的组织扩张术可以成功修复节段性周围神经缺损；2)NCV和GCF在移植和扩张/修复技术上具有可比性，尽管移植组的GMW明显高于移植组；以及3)神经扩张/修复可能被证明是一种有用的替代移植的方法。
The inherent disadvantages of nerve grafting have made it necessary to find alternative techniques for treating segmental nerve loss. This study compares the techniques of nerve grafting and nerve expansion/repair for the management of nerve injuries with segmental nerve loss in an animal model. Bilateral segmental sciatic nerve defects were created in eight dogs. On one side a 2-cm segment was excised and replaced with a nerve graft; on the other side a 2-cm defect was created with ligatures and the nerve underwent preliminary expansion and then repair. Eighteen months later nerve conduction velocity (NCV), gastrocnemius contraction force (GCF), and muscle weight (GMW) were determined for the seven surviving animals. NCV for the expanded repair was 58.66 +/- 34.18 m/sec and 47.73 +/- 7.93 for the grafted repair (p = 0.4); GCF was 619.04 +/- 353.70 gm for the expanded repair and 726.80 +/- 415.78 gm (p = 0.2) for the grafted repair; and GMW was 82.80 +/- 5.68 gm for the expanded repair and 109.55 +/- 20.63 gm (p = 0.02) for the grafted repair. The data suggest that: 1) conventional tissue expansion techniques can be used successfully to repair segmental peripheral nerve defects; 2) NCV and GCF are comparable for grafting and expansion/repair techniques although GMW is significantly higher in the grafted group; and 3) nerve expansion/repair may prove to be a useful alternative to grafting.