A catalytic versus stoichiometric photoinduced electron transfer promoted selective C16-C21 bond cleavage of catharanthine
A catalytic versus stoichiometric photoinduced electron transfer promoted selective C16-C21 bond cleavage of catharanthine
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DOI：
10.1016/s0040-4039(00)02117-1
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发表时间：
2001-01-29
影响因子：
1.8
通讯作者：
Ferroud, C
中科院分区：
文献类型：
--
作者：
Cocquet, G;Rool, P;Ferroud, C
通过长春质碱的选择性氧化C-16-C-21键断裂，描述了一种清洁和有效的进入裂解胺骨架的方法。通过使用催化量的β-拉帕醌作为光敏剂获得最佳结果。这允许成功地控制反向电子转移之间的竞争。去质子化和裂解途径。(C)2001爱思唯尔科技有限公司版权所有。
A clean and efficient access to the cleavamine skeleton is described through the selective oxidative C-16-C-21 bond cleavage of catharanthine. The best result is obtained by the use of catalytic quantities of beta -lapachone as photosensitizer. which permits the successful control of competition between the back electron transfer. the deprotonation and the fragmentation pathway. (C) 2001 Elsevier Science Ltd. All rights reserved.