Shaping volumetric light distribution through turbid media using real-time three-dimensional opto-acoustic feedback
Shaping volumetric light distribution through turbid media using real-time three-dimensional opto-acoustic feedback
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DOI：
10.1364/ol.40.000443
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发表时间：
2015-02-15
期刊：
影响因子：
3.6
通讯作者：
Razansky, Daniel
中科院分区：
文献类型：
--
作者：
Dean-Ben, X. Luis;Estrada, Hector;Razansky, Daniel
通过混浊介质聚焦光代表了现代生物光子学中一个非常迷人的挑战。光声用于深层组织中的光吸收对比度的高分辨率成像的独特能力可以提供自然且有效的反馈以控制散射介质中的光递送。虽然最近已经报道了使用光声读数作为波前整形的反馈机制的基本可行性，但是所建议的方法可能需要长的采集时间，使得它们难以转化为现实的组织环境。在试图显着加快动态波前整形能力，我们在这里提出了一种基于反馈的方法，使用实时三维光声成像辅助遗传算法为基础的优化。新技术在存在噪声测量的情况下提供了鲁棒的性能，并且可以同时控制整个体积区域中的散射波场。(C)2015美国光学学会
Focusing light through turbid media represents a highly fascinating challenge in modern biophotonics. The unique capability of opto-acoustics for high-resolution imaging of light absorption contrast in deep tissues can provide a natural and efficient feedback to control light delivery in a scattering medium. While the basic feasibility of using opto-acoustic readings as a feedback mechanism for wavefront shaping has been recently reported, the suggested approaches may require long acquisition times, making them challenging to be translated into realistic tissue environments. In an attempt to significantly accelerate dynamic wavefront shaping capabilities, we present here a feed-back-based approach using real-time three-dimensional opto-acoustic imaging assisted with genetic-algorithm-based optimization. The new technique offers robust performance in the presence of noisy measurements and can simultaneously control the scattered wave field in an entire volumetric region. (C) 2015 Optical Society of America