Characteristics of asymptomatic COVID-19 infection and progression: A multicenter, retrospective study.
Characteristics of asymptomatic COVID-19 infection and progression: A multicenter, retrospective study.
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DOI：
10.1080/21505594.2020.1802194
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发表时间：
2020-12
期刊：
影响因子：
5.2
通讯作者：
Zou Z
中科院分区：
文献类型：
--
作者：
Yu C;Zhou M;Liu Y;Guo T;Ou C;Yang L;Li Y;Li D;Hu X;Shuai L;Wang B;Zou Z
由新型冠状病毒SARS-CoV-2引起的2019年新型冠状病毒病（COVID-19）自2019年底以来在全球蔓延。无症状感染者可能破坏遏制大流行的干预措施，值得高度关注。然而，关于无症状患者的特征和预后的信息有限。因此，我们进行了回顾性研究，检索了中国武汉三家定点医院的79例无症状COVID-19入院患者的数据。无症状患者可发生在9岁至96岁的任何年龄。这些患者的丙氨酸转氨酶和c反应蛋白水平也较低。斑片状阴影是计算机断层扫描中最常见的表现。部分无症状感染者在住院期间出现轻、中度症状。年龄和合并症，特别是高血压，可能是入院时最初无症状携带者症状发展的预测因素。对这些症状前患者在症状出现前进行早期发现和治疗，可以缩短冠状病毒的传播期，减少重症病例的发生。
Novel coronavirus disease 2019 (COVID-19), caused by novel coronavirus SARS-CoV-2, has spread globally since the end of 2019. Asymptomatic carriers are of great concern as they can undermine the interventions to stop the pandemic. However, there is limited information about the characteristics and outcomes of the asymptomatic patients. Therefore, we conducted this retrospective study and retrieved data of 79 asymptomatic COVID-19 patients at admission from three designated hospitals in Wuhan, China. The asymptomatic patients could happen at any age, ranged from 9 to 96 years. These patients also had lower levels of alanine aminotransferase and C-reactive protein. Patchy shadowing was the most common manifestation in computed tomography scan. Some asymptomatic carriers developed mild or moderate symptoms during hospitalization. Age and comorbidities, especially hypertension, may be predictive factors for symptom development in the initially asymptomatic carriers at admission. Early detection and treatment for these presymptomatic patients before symptom onset can shorten the communicable period for the coronavirus and reduce the occurrence of severe cases.
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DOI：
10.15557/pimr.2020.0003
发表时间：
2020-01-01
影响因子：
3.6
作者：
通讯作者：
--
影响因子：
82.9
作者：
He, Xi;Lau, Eric H. Y.;Leung, Gabriel M.
通讯作者：
Leung, Gabriel M.
中国武汉市 138 例 2019 新型冠状病毒感染肺炎住院患者的临床特征。
影响因子：
120.7
作者：
Wang, Dawei;Hu, Bo;Peng, Zhiyong
通讯作者：
Peng, Zhiyong
影响因子：
82.9
作者：
Long, Quan-Xin;Tang, Xiao-Jun;Huang, Ai-Long
通讯作者：
Huang, Ai-Long
影响因子：
19.7
作者：
Bernheim, Adam;Mei, Xueyan;Chung, Michael
通讯作者：
Chung, Michael