Neopetrosiamine A, biologically active bis-piperidine alkaloid from the Caribbean sea sponge Neopetrosia proxima.
Neopetrosiamine A, biologically active bis-piperidine alkaloid from the Caribbean sea sponge Neopetrosia proxima.
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Neopetrosiamine A，一种来自加勒比海海绵 Neopetrosia proxima 的生物活性双哌啶生物碱。
DOI：
10.1016/j.bmcl.2010.07.084
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发表时间：
2010
影响因子：
2.7
通讯作者：
Rodriguez,AbimaelD
中科院分区：
文献类型：
--
作者：
Wei,Xiaomei;Nieves,Karinel;Rodriguez,AbimaelD
从波多黎各西海岸采集的海绵Neopetrosiaproxima中提取了一种新的四环双胡椒碱生物碱——neopetrosiamine A(1)。化合物1的结构通过光谱数据分析，并与一个著名的3-烷基-胡椒碱生物碱模型的1h和13c NMR数据进行了仔细的比较。该生物碱对多种肿瘤细胞系具有较强的体外细胞毒活性，对病原菌结核分枝杆菌和恶性疟原虫具有较强的体外抑制活性。
A new tetracyclic bis-piperidine alkaloid, neopetrosiamine A (1), has been extracted from the marine sponge Neopetrosiaproxima collected off the west coast of Puerto Rico. The structure of compound 1 was elucidated by analysis of spectroscopic data coupled with careful comparisons of its1H and13C NMR data with those of a well-known 3-alkylbis-piperidine alkaloid model. The new alkaloid displayed strong in vitro cytotoxic activity against a panel of cancer cell lines as well as in vitro inhibitory activity against the pathogenic microbes Mycobacterium tuberculosis and Plasmodium falciparum.