MULTISTEP CARCINOGENESIS - A 1992 PERSPECTIVE
MULTISTEP CARCINOGENESIS - A 1992 PERSPECTIVE
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DOI：
10.1126/science.1411570
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发表时间：
1992-10-23
期刊：
影响因子：
56.9
通讯作者：
SUGIMURA, T
中科院分区：
文献类型：
--
作者：
SUGIMURA, T
癌症是日本的主要死因。癌症发病率模式的最新变化可能反映了更西方的饮食和生活方式的趋势。在导致致癌的饮食因素中，杂环胺是一组存在于熟肉和鱼中的致突变化合物。致癌作用是一个多步骤的过程，其中细胞随着发展为更恶性的表型而积累多种遗传改变。认识到越来越多的相互作用的因素，有助于致癌可能会迫使重新考虑目前的风险评估方法。
Cancer is the leading cause of death in Japan. Recent changes in cancer incidence patterns may reflect the trend toward a more Western diet and life-style. Among the dietary factors that contribute to carcinogenesis are the heterocyclic amines, a group of mutagenic compounds present in cooked meat and fish. Carcinogenesis is a multistep process in which cells accumulate multiple genetic alterations as they progress to a more malignant phenotype. Recognition of the growing number of interacting factors that contribute to carcinogenesis may force reconsideration of current methods of risk assessment.