Characterization of Canine Adenovirus Type 2 Virus Infection Pattern in Canine and Human Cell Lines.
Characterization of Canine Adenovirus Type 2 Virus Infection Pattern in Canine and Human Cell Lines.
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DOI：
10.1155/2022/3658970
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发表时间：
2022
影响因子：
2.2
通讯作者：
Agarwal, Payal
中科院分区：
文献类型：
--
作者：
Hogans, Madison D.;Kretzschmar, Will P.;Higgins, Theresa A.;Chakrabortty, Atonu;Nance, Rebecca L.;Smith, Bruce F.;Bedi, Deepa;Sandey, Maninder;Agarwal, Payal
犬2型腺病毒（Canine adenovirus type 2，CAV 2）是一种非人腺病毒，具有感染人和犬细胞的能力。参与CAV 2转导的细胞表面受体仍然是未知的。这些的鉴定将为开发增强的基因递送工具和更好地理解CAV 2生物学提供有价值的信息。基于CAV 2可以使用CAR传播的知识，CAV 2被错误地与Ad 5分组。因此，我们评估了CAV 2和Ad 5（CAV 2GFP，Ad 5G/L）在各种犬和人细胞系中的感染模式，以确定它们的不同向性。我们的研究表明，CAV 2可以成功感染Ad 5不感染的细胞，并且CAV 2感染与CAR表达无关。CAV 2可以感染具有低或最小CAR表达的细胞。我们的数据表明，CAV 2转导不依赖于CAR受体，因此，找到新的CAV 2受体至关重要。
Canine adenovirus type 2 (CAV2) is a nonhuman adenovirus with a known ability to infect human and canine cells. The cell surface receptors involved in CAV2 transduction are still unknown. Identification of these would provide valuable information to develop enhanced gene delivery tools and better understand CAV2 biology. CAV2 is erroneously grouped with Ad5 based on the knowledge that CAV2 may transduce using CAR. Therefore, we have evaluated CAV2 and Ad5 (CAV2GFP, Ad5G/L) infection patterns in various canine and human cell lines to determine their different tropisms. Our research demonstrates that CAV2 can successfully infect cells that Ad5 does not infect, and CAV2 infections do not correlate with CAR expression. CAV2 can infect cells that have a low or minimal expression of CAR. Our data suggest that CAV2 transduction is not dependent on the CAR receptor, and thus, it is crucial to find novel CAV2 receptors.
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DOI：
10.3390/v6083293
发表时间：
2014-08-21
期刊：
Viruses
影响因子：
--
作者：
Lewis TB;Glasgow JN;Harms AS;Standaert DG;Curiel DT
通讯作者：
Curiel DT
影响因子：
5.4
作者：
Schoelm, Guy;El Bakkouri, Majida;Kremer, Eric J.
通讯作者：
Kremer, Eric J.
影响因子：
--
作者：
Southgate, Thomas;Kroeger, Kurt M;Castro, Maria G
通讯作者：
Castro, Maria G
影响因子：
1.2
作者：
Szelechowski, Marion;Bergeron, Corinne;Klonjkowski, Bernard
通讯作者：
Klonjkowski, Bernard
影响因子：
2.7
作者：
Agarwal P;Crepps MP;Stahr NA;Kretzschmar WP;Harris HC;Prasad N;Levy SE;Smith BF
通讯作者：
Smith BF