Systemic daily morphine enhances the analgesic effect of intrathecal dexmedetomidine via up‐regulation of alpha 2 adrenergic receptor subtypes A, B and C in dorsal root ganglion and dorsal horn
Systemic daily morphine enhances the analgesic effect of intrathecal dexmedetomidine via up‐regulation of alpha 2 adrenergic receptor subtypes A, B and C in dorsal root ganglion and dorsal horn
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DOI：
10.1111/j.2042-7158.2010.01192.x
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发表时间：
2010-12
影响因子：
3.3
通讯作者：
S. Tamagaki;Takahiro Suzuki;S. Hagihira;Y. Hayashi;T. Mashimo
中科院分区：
文献类型：
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作者：
S. Tamagaki;Takahiro Suzuki;S. Hagihira;Y. Hayashi;T. Mashimo
目的研究α2肾上腺素能受体（α2 AR）激动剂对吗啡耐受小鼠的作用。然而，促成因素尚未查明。本研究观察了重复全身吗啡是否影响鞘内注射右美托咪定的镇痛效力以及小鼠背根神经节和背角中A、B和C亚型α2 AR（α 2 A、α 2 B和α 2 C AR）的表达。
Objectives It has been reported that the effect of intrathecally administered α2 adrenergic receptor (α2 AR) agonists is enhanced in mice that are chronically tolerant to systemic morphine. However, contributory factors have not been identified. Here we examined whether repeated systemic morphine affected the analgesic potency of intrathecal dexmedetomidine and the expression of subtype A, B and C α2 AR (α2A, α2B and α2C AR) in the dorsal root ganglion and dorsal horn in mice.