On the shear rate dependence of red cell aggregation in vitro.
On the shear rate dependence of red cell aggregation in vitro.
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DOI：
10.1172/jci105836
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发表时间：
1968-06
期刊：
影响因子：
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通讯作者：
H. Schmid-schönbein;P. Gaehtgens;H. Hirsch
中科院分区：
文献类型：
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作者：
H. Schmid-schönbein;P. Gaehtgens;H. Hirsch
血液的非牛顿粘度，即，认为在低流速下表观粘度的升高是红细胞在低速度梯度（剪切速率）下可逆聚集的结果。通过使锥板粘度计透明，可以直接观察在规定剪切速率下流动的血液。红细胞聚集体，发生在所有情况下，在低流量，可逆地分散通过增加剪切速率。这种行为与抗凝剂的添加无关，但可以通过改变血浆蛋白组成来改变。血清中的红细胞不形成聚集体;这种非聚集性样品在低剪切速率下确实显示粘度增加。由于沉降速率受许多参数的影响，因此在描述红细胞聚集时并不可靠。红细胞的聚集与血浆和细胞的显著分离有关。这种分离对锥板粘度有相当大的影响。
Non-Newtonian viscosity of blood, i.e., the rise in apparent viscosity at low flow, was believed to be a result of reversible aggregation of red cells at low velocity gradients (shear rate). By making a cone-plate viscometer transparent, direct observation was made possible of the blood flowing under defined shear rates. Red cell aggregates, occurring in all cases at low flow, were reversibly dispersed by increasing the shear rate. This behavior was independent of the addition of anticoagulants, but it could be altered by changing the plasma protein composition. Red cells in serum did not form aggregates; such nonaggregating samples did show an increase in viscosity at low shear rates. Since the sedimentation rate can be influenced by many parameters, it is not reliable in describing red cell aggregation. Aggregation of red cells is linked with a marked separation of plasma and cells. Such a separation is of considerable influence on cone-plate viscometry.