Clinical Characteristics Associated with Long-term Survival in Metastatic Gastric Cancer after Systemic Chemotherapy.
Clinical Characteristics Associated with Long-term Survival in Metastatic Gastric Cancer after Systemic Chemotherapy.
复制标题
与全身化疗后转移性胃癌长期生存相关的临床特征。
DOI：
10.7314/apjcp.2015.16.13.5433
复制
发表时间：
2015
期刊：
影响因子：
--
通讯作者：
K. Muro
中科院分区：
文献类型：
--
作者：
S. Kadowaki;A. Komori;D. Takahari;T. Ura;S. Ito;M. Tajika;Y. Niwa;I. Oze;K. Muro
背景
转移性胃癌（MGC）患者的全身化疗通常是姑息性的，尽管一些患者在治疗后经历了长期生存。因此，我们确定了与MGC患者姑息化疗后长期生存相关的临床特征。
材料和方法
我们回顾性分析了2001年至2008年在我院接受全身化疗的514例MGC患者。为了确定生存期超过2年的临床预测因素，进行了多变量logistic回归分析，并估计了化疗后MGC患者的5年生存率。
结果
在514例患者中，分别有96例（19%）和16例（3%）存活超过2年和5年，（比值比[OR]=3.39; p=0.01），既往胃切除术（OR=1.86; p=0.01）、单一转移部位（OR=1.80; p=0.03）和正常碱性磷酸酶水平（OR=2.81; p<0.01）被确定为长期生存的独立预测因素。在16名5年生存者中，6名在研究结束时仍然活着，尽管停止了化疗，但没有显示出疾病的证据。
结论
目前的数据表明，不同的临床特征与MGC患者的长期生存，并表明姑息化疗可以治愈高度选择的患者。
BACKGROUND
Systemic chemotherapy for patients with metastatic gastric cancer (MGC) is generally palliative, although some patients experience long-term survival after treatment. Thus, we identified clinical characteristics that are associated with long-term survival of patients with MGC after palliative chemotherapy.
MATERIALS AND METHODS
We retrospectively reviewed 514 MGC patients who received systemic chemotherapy at our institution from 2001 to 2008. To identify clinical predictors of survival beyond 2 years, multivariate logistic regression analyses were performed, and 5-year survival rates were estimated among MGC patients following chemotherapy.
RESULTS
Among 514 patients, 96 (19%) and 16 (3%) survived beyond 2 and 5 years, respectively, and performance status of 0 or 1 (odds ratio [OR]=3.39; p=0.01), previous gastrectomy (OR=1.86; p=0.01), single metastatic site (OR=1.80; p=0.03), and normal alkaline phosphatase levels (OR=2.81; p<0.01) were identified as independent predictors of long-term survival. Of the 16 5-year survivors, six were alive at the end of the study and showed no evidence of disease despite cessation of chemotherapy.
CONCLUSIONS
The present data demonstrate distinct clinical characteristics that are associated with long-term survival of MGC patients, and indicated that palliative chemotherapy can be curative in highly selected patients.
影响因子：
51.1
作者：
Koizumi, Wasaburo;Narahara, Hiroyuki;Takeuchi, Masahiro
通讯作者：
Takeuchi, Masahiro