Relations of plasma total TIMP-1 levels to cardiovascular risk factors and echocardiographic measures:: the Framingham heart study
Relations of plasma total TIMP-1 levels to cardiovascular risk factors and echocardiographic measures:: the Framingham heart study
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DOI：
10.1016/j.ehj.2004.05.029
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发表时间：
2004-09-01
影响因子：
39.3
通讯作者：
Vasan, RS
中科院分区：
文献类型：
--
作者：
Sundström, J;Evans, JC;Vasan, RS
金属蛋白酶组织抑制剂-1（TIMP-1）是细胞外基质降解的关键调节因子。我们研究了血浆总TIMP-1的关系，心血管危险因素和超声心动图左心室（LV）的结构和功能在社区为基础的samples.Methods和结果我们研究了1069心脏研究参与者（平均年龄56岁，58%的妇女）的心脏衰竭和以前的心肌梗死。男性血浆TIMP-1水平高于女性，且随年龄、体重指数和总胆固醇/高密度脂蛋白胆固醇比值的增加而升高，但随饮酒量的增加而降低。血浆TIMP-1也与吸烟、糖尿病和抗高血压治疗的使用直接相关。校正年龄、性别和身高后，血浆TIMP-1与左室质量、瓦特厚度、相对瓦特厚度、收缩末期内径和左房内径以及左室舒张末期内径增加或室壁厚度增加的风险呈正相关，与缩短分数呈负相关。临床协变量的额外调整衰减的关系，血浆TIMP-1最超声measurements.Conclusions在我们的横断面调查，血浆总TIMP-1与主要的心血管危险因素和指标的LV肥大和收缩功能障碍。这增加了心血管危险因素可能通过细胞外基质降解影响心血管重塑的可能性，这可能反映在血浆TIMP-1水平上。(C)2004年欧洲心脏病学会。由爱思唯尔有限公司出版。保留所有权利。
Aims Tissue inhibitor of metalloproteinases-1 (TIMP-1) is a key regulator of extracellular matrix degradation. We examined relations of plasma total TIMP-1 to cardiovascular risk factors and echocardiographic Left ventricular (LV) structure and function in a community-based sample.Methods and results We studied 1069 Framingham Heart Study participants (mean age 56 years, 58% women) free of heart failure and previous myocardial infarction. Plasma TIMP-1 was higher in men compared with women, and increased with age, body mass index and total/HDL-cholesterol ratio, but decreased with alcohol intake. plasma TIMP-1 was also directly related to smoking, diabetes and use of anti-hypertensive treatment. Adjusting for age, sex and height, plasma TIMP-1 was positively associated with LV mass, watt thickness, relative watt thickness, end-systolic diameter, and left atrial diameter and the risk of having increased LV end-diastolic diameter or increased wall thickness, and negatively correlated with fractional shortening. Additional adjustment for clinical covariates attenuated the relations of plasma TIMP-1 to most echocardiographic measures.Conclusions In our cross-sectional investigation, plasma total TIMP-1 was related to major cardiovascular risk factors and to indices of LV hypertrophy and systolic dysfunction. This raises the possibility that cardiovascular risk factors may influence cardiovascular remodelling via extracellular matrix degradation, which may be reflected in plasma TIMP-1 levels. (C) 2004 The European Society of Cardiology. Published by Elsevier Ltd. All rights reserved.