Cytogenetic biomonitoring carried out in a village (Dolon) adjacent to the Semipalatinsk nuclear weapon test site
Cytogenetic biomonitoring carried out in a village (Dolon) adjacent to the Semipalatinsk nuclear weapon test site
复制标题
在塞米巴拉金斯克核武器试验场附近的一个村庄（多隆）进行细胞遗传学生物监测
DOI：
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发表时间：
2001
影响因子：
1.7
通讯作者：
M. Akhmetov
中科院分区：
文献类型：
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作者：
A. Testa;L. Stronati;R. Ranaldi;M. Spanò;F. Steinhäusler;M. Gastberger;A. Hubmer;L. Ptitskaya;M. Akhmetov
塞米巴拉金斯克地区（哈萨克斯坦共和国）因450多次核试验而受到广泛的放射性污染，其中近100次在大气中爆炸。本研究结果涉及对多隆人口的一个研究队列进行的细胞遗传学评估，多隆是位于核武器试验场东北边界的一个定居点，主要由于1949年苏联第一次核试验，该定居点受到电离辐射剂量升高。对自核试验开始以来居住在多隆的21名个人（50岁以上）的血样进行了常规细胞遗传学分析。一个匹配的对照组包括生活在非污染地区的20个人。与对照组相比，Dolon队列中发现染色体畸变的频率更高，尽管它们仍在老年人大型正常人群研究报告的背景水平范围内。
Abstract The Semipalatinsk region (Kazakhstan Republic) has been affected by extensive radioactive contamination due to more than 450 nuclear tests of which almost 100 were exploded in the atmosphere. The present results refer to cytogenetic assessments in a study cohort of the population of Dolon, a settlement located on the NE boundary of the nuclear weapon test site, which was exposed to elevated doses of ionising radiation primarily due to the first Soviet nuclear test in 1949. Conventional cytogenetic analyses were carried out on 21 blood samples from individuals (more than 50 years old) living in Dolon since the very beginning of nuclear testing. A matched control group included 20 individuals living in non-contaminated areas. Higher frequencies of chromosome aberrations were found in the Dolon cohort compared to the control group, even though they remain within the range of the background levels reported for large normal human population studies on elderly individuals.