Properties of face localizer activations and their application in functional magnetic resonance imaging (fMRI) fingerprinting
Properties of face localizer activations and their application in functional magnetic resonance imaging (fMRI) fingerprinting
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DOI：
10.1371/journal.pone.0214997
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发表时间：
2019-04
期刊：
影响因子：
3.7
通讯作者：
Lena Schwarz;B. Kreifelts;D. Wildgruber;M. Erb;K. Scheffler;T. Ethofer
中科院分区：
文献类型：
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作者：
Lena Schwarz;B. Kreifelts;D. Wildgruber;M. Erb;K. Scheffler;T. Ethofer
在涉及人脸处理的功能磁共振成像(FMRI)研究中，功能定位器尤其普遍。在这项研究中，我们在四个重要方面扩展了关于面孔定位的知识：第一，枕叶和梭形面孔区域(OFA/FFA)和杏仁核的激活差异表现为更多的激活，而楔叶前叶和内侧前额叶皮质对面孔的失活比对照刺激少。面部选择性后颞上沟是一个混合区，在其下方表现出更多的激活，而在其上方表现出更少的失活。其次，所使用的控制刺激可以影响一个区域是否在组分析中被归类为面孔选择性。我们专门对最近描述的梭形皮质细胞构筑亚区(FG-2/FG-4)进行了研究。FG-4中体素间的平均活动对于脸部来说比物体、房屋或风景更强。在FG-2中，与景观相比，平均活动仅显著增强，但该区域内的小峰被检测到，用于与物体和房屋进行比较。第三，单个峰激活的重复性对于右FFA是非常好的，对于右OFA是相当好的，而在所有其他区域中，它太低了，不能提供关于时不变的单个峰的有效信息。最后，右侧OFA和FFA中的细粒度空间激活模式在每个个体内都是时间不变的，并且个体之间的差异足够大，从而能够以近乎完美的精度识别个体参与者(fMRI指纹)。
Functional localizers are particularly prevalent in functional magnetic resonance imaging (fMRI) studies concerning face processing. In this study, we extend the knowledge on face localizers regarding four important aspects: First, activation differences in occipital and fusiform face areas (OFA/FFA) and amygdala are characterized by increased activation while precuneus and medial prefrontal cortex show decreased deactivation to faces versus control stimuli. The face-selective posterior superior temporal sulcus is a hybrid area exhibiting increased activation within its inferior and decreased deactivation within its superior part. Second, the employed control stimuli can impact on whether a region is classified in group analyses as face-selective or not. We specifically investigated this for recently described cytoarchitectonic subregions of the fusiform cortex (FG-2/FG-4). Averaged activity across voxels in FG-4 was stronger for faces than objects, houses, or landscapes. In FG-2, averaged activity was only significantly stronger in comparison with landscapes, but small peaks within this area were detected for comparison versus objects and houses. Third, reproducibility of individual peak activations is excellent for right FFA and quite good for right OFA, whereas within all other areas it was too low to provide valid information on time-invariant individual peaks. Finally, the fine-grained spatial activation patterns in right OFA and FFA are both time-invariant within each individual and sufficiently different between individuals to enable identification of individual participants with near-perfect precision (fMRI fingerprinting).