Prostate cancer: Alternatively spliced mRNA transcripts in tumor progression and their uses as therapeutic targets.
Prostate cancer: Alternatively spliced mRNA transcripts in tumor progression and their uses as therapeutic targets.
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DOI：
10.1016/j.biocel.2021.106096
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发表时间：
2021-12
期刊：
影响因子：
--
通讯作者：
Wang BD
中科院分区：
文献类型：
--
作者：
Calderon-Aparicio A;Wang BD
前列腺癌是美国男性中最常诊断出的癌症，也是癌症死亡的第二大原因。目前的疗法显示出早期抗肿瘤反应，但最终导致患者出现治疗抵抗、复发和较差的生存率。替代RNA剪接是一种通过从单个基因产生多个转录本来增加蛋白质组多样性的细胞机制，与前列腺癌的发生/进展有关。报告显示，许多异常的 mRNA 剪接变体在前列腺癌中上调，通过增强增殖、转移、肿瘤生长、抗凋亡和/或治疗抵抗来促进恶性肿瘤。在这里，我们讨论前列腺癌发病机制中异常剪接机制的致癌特性，以及剪接变体作为潜在诊断和治疗靶点的用途。最后，我们讨论了针对异常剪接机制的药理学和分子方法，作为纠正剪接错误和克服耐药性的有效疗法，最终改善前列腺癌患者的临床结果。
Prostate cancer is the most frequently diagnosed cancer and second leading cause of cancer deaths among American men. Current therapies show early antitumor responses, but ultimately lead to treatment resistance, relapse and poorer survival in patients. Alternative RNA splicing, a cell mechanism increasing the proteome diversity by producing multiple transcripts from a single gene, has been associated with prostate cancer development/progression. Reports showed that many aberrant mRNA splice variants are upregulated in prostate cancer, promoting malignancy through enhanced proliferation, metastasis, tumor growth, anti-apoptosis, and/or treatment resistance. Here, we discuss the oncogenic properties of aberrant splicing mechanisms underlying prostate cancer pathogenesis, as well as the uses of the splicing variants as potential diagnostics and treatment targets. Finally, we discuss the pharmacologic and molecular approaches for targeting aberrant splicing mechanisms as effective therapies to correct the splicing errors and overcome the drug resistance, ultimately improving the clinical outcome of prostate cancer patients.
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DOI：
10.1158/1078-0432.ccr-17-0017
发表时间：
2017-08-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Kohli M;Ho Y;Hillman DW;Van Etten JL;Henzler C;Yang R;Sperger JM;Li Y;Tseng E;Hon T;Clark T;Tan W;Carlson RE;Wang L;Sicotte H;Thai H;Jimenez R;Huang H;Vedell PT;Eckloff BW;Quevedo JF;Pitot HC;Costello BA;Jen J;Wieben ED;Silverstein KAT;Lang JM;Wang L;Dehm SM
通讯作者：
Dehm SM
影响因子：
3.7
作者：
Araki S;Dairiki R;Nakayama Y;Murai A;Miyashita R;Iwatani M;Nomura T;Nakanishi O
通讯作者：
Nakanishi O
影响因子：
50.3
作者：
Cato, Laura;de Tribolet-Hardy, Jonas;Brown, Myles
通讯作者：
Brown, Myles
DOI：
10.1073/pnas.0506281103
发表时间：
2006-02-14
影响因子：
11.1
作者：
Burd, CJ;Petre, CE;Knudsen, KE
通讯作者：
Knudsen, KE
影响因子：
8
作者：
Brambilla, C;Folini, M;Zaffaroni, N
通讯作者：
Zaffaroni, N