Association of drusen deposition with choroidal intercapillary pillars in the aging human eye
Association of drusen deposition with choroidal intercapillary pillars in the aging human eye
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DOI：
10.1167/iovs.03-1083
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发表时间：
2004-09-01
影响因子：
4.4
通讯作者：
Jeffery, G
中科院分区：
文献类型：
--
作者：
Lengyel, I;Tufail, A;Jeffery, G
目的。方法：采用常规显微镜和共聚焦显微镜对42~95岁年龄段供眼的脉络膜毛细血管和Bruch膜的水合制剂进行观察，探讨玻璃体沉积的起始部位及其与脉络膜毛细血管的关系。结果：在所研究的所有年龄组中，在赤道出现了自发荧光的玻璃体，但在中心血管结构不同的地方没有发现，呈管状而不是蜂窝状。脉络膜毛细血管侧壁(通常称为脉络膜毛细血管间的毛细血管间柱)与自身荧光斑疹密切相关(P=0.028；Wilcoxon Signed RANSING检验)。非荧光性玻璃体偶尔可见于中央，但不易辨认，而且由于其体积较大，其相对于毛细血管壁的定位是不可能的。结论：这些结果有力地支持了自体荧光玻璃体不是随机分布的概念，并且与脉络膜血管壁有特定的空间关系。赤道斑疹发出荧光，而中央斑疹没有，这表明它们在两个部位可能有不同的化学成分，在老年性黄斑疾病中可能有不同的意义。
PURPOSE. To determine the pattern of drusen accumulation with age and to investigate the initial sites of deposition and their relationship to choroidal capillaries in human donor eyes from the eye bank of Moorfields Eye Hospital.METHODS. Wholemounted, hydrated preparations of the choriocapillaris and Bruch's membrane from donor eyes ranging from 42 to 95 years, with or without retinal pigment epithelium (RPE), were examined by conventional and confocal microscopy. Drusen were visualized by their autofluorescence.RESULTS. In all age groups studied autofluorescent drusen were present at the equator but were not found centrally where the vascular architecture is different, being tubular rather than a honeycomb pattern. Autofluorescing drusen were strongly associated with the lateral walls of the choriocapillaris (an area commonly known as the intercapillary pillars of the choriocapillaris (P = 0.028; Wilcoxon signed ranks test). Nonfluorescing drusen were occasionally seen centrally, but were not easily identified, and because of their large size, their localization with respect to capillary walls was not possible.CONCLUSIONS. These results strongly support the notion that autofluorescent drusen are not randomly distributed and have a specific spatial relationship to choroidal vessel walls. That equatorial drusen fluoresce, whereas central drusen do not, suggests that they may have different chemical compositions at the two sites and possibly different significance in age-related macular disease.