Spectral Tuning of Azobenzene Photoswitches for Biological Applications
Spectral Tuning of Azobenzene Photoswitches for Biological Applications
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DOI：
10.1002/anie.200805013
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发表时间：
2009-01-01
影响因子：
16.6
通讯作者：
Woolley, G. Andrew
中科院分区：
文献类型：
--
作者：
Sadovski, Oleg;Beharry, Andrew A.;Woolley, G. Andrew
通过在4，4 ′-二氨基取代偶氮苯中引入2，2 ′-氨烷基取代基，获得了较长的转换波长和较好的光化学产率以及在还原性水溶液中的稳定性.因此，这些产品适用于细胞内环境中生物分子结构的光控制，例如在两种肽构型之间切换（见图）。
Longer switching wavelengthsand good photochemical yields and stabilities of thecisisomers in reducing aqueous environments are achieved by introducing 2,2′‐aminoalkyl substituents into 4,4′‐diamido‐substituted azobenzenes. The products are thus suitable for photocontrol of biomolecular structures in intracellular environments, such as switching between two peptide configurations (see picture).