Undercutting efforts of precision medicine: roadblocks to minority representation in breast cancer clinical trials.
Undercutting efforts of precision medicine: roadblocks to minority representation in breast cancer clinical trials.
复制标题
削弱精准医学的努力：乳腺癌临床试验中少数群体代表性的障碍。
DOI：
10.1007/s10549-021-06264-x
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发表时间：
2021
影响因子：
3.8
通讯作者：
Aneja,Ritu
中科院分区：
文献类型：
--
作者：
Saini,Geetanjali;Gogineni,Keerthi;Kittles,RickA;Aneja,Ritu
精确（或个性化）医学在乳腺癌治疗中有很大的希望。个性化医疗的成功取决于临床试验中少数群体的包容性和代表性。在这篇文章中，我们专注于非洲裔美国人人口的障碍，包括乳腺肿瘤学试验的准入和招募障碍，种族和民族的流行分类，以及通过采用遗传祖先映射工具来更准确地确定种族或民族来完善整体分类的必要性。
Precision (or personalized) medicine holds great promise in the treatment of breast cancer. The success of personalized medicine is contingent upon inclusivity and representation for minority groups in clinical trials. In this article, we focus on the roadblocks for the African American demographic, including the barriers to access and enrollment in breast oncology trials, the prevailing classification of race and ethnicity, and the need to refine monolithic categorization by employing genetic ancestry mapping tools for a more accurate determination of race or ethnicity.