Current landscape for T-cell targeting in autoimmunity and transplantation.
Current landscape for T-cell targeting in autoimmunity and transplantation.
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DOI：
10.2217/imt.11.61
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发表时间：
2011-07
期刊：
影响因子：
2.8
通讯作者：
Miller SD
中科院分区：
文献类型：
--
作者：
Getts DR;Shankar S;Chastain EM;Martin A;Getts MT;Wood K;Miller SD
近年来，T细胞免疫抑制策略及其转化为常规临床实践的重大进展彻底改变了自身免疫性疾病和实体器官移植的管理和结果。超过80种疾病被认为与自身免疫性病因有关，因此自身免疫相关的发病率和死亡率在发达国家排名第三，仅次于心血管疾病和癌症。实体器官移植已成为许多终末期器官疾病的治疗选择。短期结果如患者和同种异体移植物1年生存率、急性排斥反应率以及疾病进展和症状控制的时间进程均稳步改善。然而，尽管使用了较新的免疫抑制药物组合，但长期同种异体移植物存活率的改善和自身免疫的完全消退仍然难以实现。此外，非特异性靶向免疫抑制药物的长期使用与显著的不良反应以及发病率和死亡率增加相关。在本文中，我们讨论了当前用于免疫抑制的临床工具，并尝试诱导长期T细胞耐受性诱导，以及未来急需的方法来生产更多短效、抗原特异性药物，这可能会优化临床结果。
In recent years, substantial advances in T-cell immunosuppressive strategies and their translation to routine clinical practice have revolutionized management and outcomes in autoimmune disease and solid organ transplantation. More than 80 diseases have been considered to have an autoimmune etiology, such that autoimmune-associated morbidity and mortality rank as third highest in developed countries, after cardiovascular diseases and cancer. Solid organ transplantation has become the therapy of choice for many end-stage organ diseases. Short-term outcomes such as patient and allograft survival at 1 year, acute rejection rates, as well as time course of disease progression and symptom control have steadily improved. However, despite the use of newer immunosuppressive drug combinations, improvements in long-term allograft survival and complete resolution of autoimmunity remain elusive. In addition, the chronic use of nonspecifically targeted immunosuppressive drugs is associated with significant adverse effects and increased morbidity and mortality. In this article, we discuss the current clinical tools for immune suppression and attempts to induce long-term T-cell tolerance induction as well as much-needed future approaches to produce more short-acting, antigen-specific agents, which may optimize outcomes in the clinic.
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影响因子：
--
作者：
Bielekova, Bibiana;Howard, Thomas;Packer, Amy N.;Richert, Nancy;Blevins, Gregg;Ohayon, Joan;Waldmann, Thomas A.;McFarland, Henry F.;Martin, Roland
通讯作者：
Martin, Roland
影响因子：
6.1
作者：
Abou-Ayache, Ramzi;Buchler, Mathias;Touchard, Guy
通讯作者：
Touchard, Guy
影响因子：
6.2
作者：
Ciancio, G;Burke, GW;Miller, J
通讯作者：
Miller, J
影响因子：
2.1
作者：
Arslan, Emrah;Klimczak, Aleksandra;Siemionow, Maria
通讯作者：
Siemionow, Maria
影响因子：
6.2
作者：
Birkeland, SA
通讯作者：
Birkeland, SA