Incidence and risk factors of synchronous colorectal cancer in patients with esophageal cancer: an analysis of 480 consecutive colonoscopies before surgery
Incidence and risk factors of synchronous colorectal cancer in patients with esophageal cancer: an analysis of 480 consecutive colonoscopies before surgery
复制标题
食管癌患者同步性结直肠癌的发病率及危险因素：480例术前连续结肠镜检查分析
DOI：
10.1007/s10147-016-1015-8
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发表时间：
2016
期刊：
影响因子：
3.3
通讯作者：
Baba H.
中科院分区：
文献类型：
--
作者：
Yoshida N;Tamaoki Y;Baba Y;Sakamoto Y;Miyamoto Y;Iwatsuki M;Shono T;Miyamoto H;Imuta M;Kurashige J;Sawayama H;Tokunaga R;Watanabe M;Sasaki Y;Yamashita Y;Baba H.
BackgroundThe精确的发病率多原发性结直肠癌在食管癌patients.MethodsIn总数，480例食管癌手术切除的熊本大学医院接受术前全结肠镜检查结直肠疾病的评估之间的2005年4月和2016年2月。我们回顾性调查了大肠癌与食道癌同时发生的情况。此外，我们研究了多原发性结直肠cancer.ResultsOf 480例患者的发病率的危险因素，14（2.9%）有同步结直肠癌，13例分化良好的管状腺癌，和1乳头状腺癌。异时性结直肠癌14例。目前的发病率的同步和总（同步和异时）结直肠癌的人数超过了正常健康人群和食管癌患者，以前报告的日本食管学会。年龄≥70岁（风险比4.82，95%可信区间1.473-15.78;p= 0.009）和Brinkman指数≥800（风险比3.47，95%可信区间1.056-11.37;p= 0.040）是同时性结直肠癌发病的独立危险因素。它们也是总结直肠癌发病率的独立危险因素。ConclusionsThe本研究的结果表明，全结肠镜检查的预处理筛选是有意义的食管癌患者，因为同步结直肠癌的频率是不可忽略的。特别是对于>70岁且有严重吸烟史的患者，可能需要进行结肠镜检查。
BackgroundThe precise incidence rates of multiple primary colorectal cancers in esophageal cancer patients are unknown.MethodsIn total, 480 consecutive patients with esophageal cancers surgically resected in the Kumamoto University Hospital received preoperative total colonoscopy for the assessment of colorectal disease between April 2005 and February 2016. We retrospectively investigated the occurrence of synchronous colorectal cancer with esophageal cancer. In addition, we examined the risk factors for the incidence of multiple primary colorectal cancers.ResultsOf the 480 patients, 14 (2.9 %) had synchronous colorectal cancers, 13 had well-differentiated tubular adenocarcinomas, and 1 had papillary adenocarcinoma. Other 14 patients had metachronous colorectal cancer. The current incidence rates of synchronous and total (both synchronous and metachronous) colorectal cancers outnumbered those in normal healthy population and those in esophageal cancer patients which previously reported by The Japan Esophageal Society. The age ≥70 years (hazard ratio 4.82, 95 % confidence interval 1.473–15.78;p= 0.009) and Brinkman index ≥800 (hazard ratio 3.47, 95 % confidence interval 1.056–11.37;p= 0.040) were the independent risk factors for the incidence of synchronous colorectal cancer. They were also the independent risk factors for the incidence of total colorectal cancer.ConclusionsThe results of the present study suggested that pretreatment screening with total colonoscopy is meaningful for patients with esophageal cancer, because the frequency of synchronous colorectal cancer was not negligible. Particularly, in patients >70 years and with history of heavy smoking, pretreatment colonoscopy might be necessary.