Natural history of Q fever in goats
Natural history of Q fever in goats
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DOI：
10.1089/153036603765627415
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发表时间：
2003-03-01
影响因子：
2.1
通讯作者：
Marrie, TJ
中科院分区：
文献类型：
--
作者：
Hatchette, T;Campbell, N;Marrie, TJ
在1999年春天，Q热的爆发导致30流产174（17%）山羊在山羊合作社在纽芬兰。这项研究的目的是确定自然。山羊贝氏柯克斯体感染史在Q热爆发后，一个农场的24只山羊在接下来的两个开玩笑的季节里被跟踪。I期和II期C的抗体。用间接免疫荧光法检测贝氏锥虫，并对胎盘样品进行C.贝氏隐孢子虫和聚合酶链反应鉴定。贝氏菌DNA I期抗体以高水平存在并在研究期间维持，而II期抗体水平在60%的感染山羊中下降至血清阴性范围。分子生物学研究表明，C。感染山羊胎盘中的贝氏体似乎仅限于爆发后的下一个开玩笑的季节。因此，我们得出结论，C.山羊的贝氏体感染似乎仅限于两个开玩笑的季节。I期抗体水平维持不变，而II期抗体水平下降。关键词：Q热-山羊-布氏柯克斯体
During the spring of 1999, an outbreak of Q fever resulted in 30 abortions among 174 (17%) goats in a caprine cooperative in Newfoundland. The intent of this study was to determine the natural. history of Coxiella burnetii infection in goats. Twenty-four goats on one farm were followed through the next two kidding seasons following the Q fever outbreak. Antibodies to phases I and II C. burnetii were determined using an indirect immunofluorescence assay and samples of placentas were cultured for C. burnetii and polymerase chain reaction was used to identify C. burnetii DNA. Phase I antibody was present in high levels and was maintained over the study period, while phase II antibody levels declined to the seronegative range in 60% of the infected goats. Molecular studies suggest that excretion of C. burnetii in the placenta of Infected goats seems to be limited to the next kidding season following an outbreak. We therefore conclude that C. burnetii infection in goats seems to be limited to two kidding seasons. Phase I antibody levels are maintained, while phase II antibody levels decline. Key words: Q Fever-Goats-Coxiella bumetii.