CAUSES OF CELL-DAMAGE IN HYPOXIA ISCHEMIA, AGING AND ALZHEIMERS-DISEASE
CAUSES OF CELL-DAMAGE IN HYPOXIA ISCHEMIA, AGING AND ALZHEIMERS-DISEASE
复制标题
DOI：
10.1016/0197-4580(89)90147-4
复制
发表时间：
1989-09-01
影响因子：
4.2
通讯作者：
GIBSON, G
中科院分区：
文献类型：
--
作者：
GIBSON, G
细胞损伤的兴奋性毒性神经递质理论的修正对于解释阿尔茨海默病的异常是必要的。阿尔茨海默氏症脑中氧化代谢酶的减少和随后的组织毒性缺氧可能是与神经递质变化的病理生理联系。类似的机制可能是老年大脑对代谢损伤更敏感的基础，这种相互作用可能解释了阿尔茨海默病与年龄相关的性质。
Modifications of the excitotoxic neurotransmitter theory of cellular damage are necessary to explain abnormalities in Alzheimer's disease. Reductions in enzymes of oxidative metabolism in Alzheimer brain and the subsequent histotoxic hypoxia may be a pathophysiological link to the neurotransmitter changes. Similar mechanisms may underlie the greater susceptibility of the aged brain to metabolic insults and this interaction may explain the age-related nature of Alzheimer's disease.