THE EFFECT OF WHEEL RUNNING AND THE ESTROUS-CYCLE ON ENERGY-EXPENDITURE IN FEMALE RATS
THE EFFECT OF WHEEL RUNNING AND THE ESTROUS-CYCLE ON ENERGY-EXPENDITURE IN FEMALE RATS
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DOI：
10.1016/0031-9384(89)90265-5
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发表时间：
1989-08-01
影响因子：
2.9
通讯作者：
DECOMBAZ, J
中科院分区：
文献类型：
--
作者：
ANANTHARAMANBARR, HG;DECOMBAZ, J
在雌性大鼠中，食物摄入和车轮运行随着发情周期而波动，产生振荡能量平衡状态。比较了发情周期对常规饲养大鼠（S）和使用活动轮的大鼠（A）能量消耗的影响。在24周内，各组的体重增加相似，尽管在研究结束时A的体脂含量比S低30 g。在通过间接热量测定法评估能量消耗期间，发情周期被中断，食物摄入和轮运行减少。然而，得出了支出与车轮运转之间的相关性，从中得出了活动成本（21千焦/千克/公里），并据此将数据外推到正常情况。这表明，平均运行6214转/天的A比S多消耗大约64千焦/天。他们通过增加6克/天（70千焦/天）的食物摄入量来补偿这一点。在整个发情周期中，轮跑在发情前期最大，发情后期最小，观察到相反的摄入趋势。发情后期和发情前期之间能量平衡的周期差异估计相当于“维持”需求的23%。因此，自发活动对日常能量平衡有显著影响，但长期影响不大，因为雌性大鼠的摄入量是精确调节的，以满足支出。
In female rats, food intake and wheel running fluctuate with the estrous cycle, creating a state of oscillating energy balance. The effect of the estrous cycle on the energy expenditure of conventionally housed rats (S) and of rats given access to an activity wheel (A) was compared. Over 24 weeks, the weight gain of the groups was similar although the body fat content of A was 30 g lower than that of S at the end of the study. During the assessment of energy expenditure by indirect calorimetry estrous cycles were disrupted and food intake and wheel running reduced. However, a correlation between expenditure and wheel running was obtained from which the cost of activity was derived (21 kJ/kg/km) and from which data were extrapolated to normal circumstances. This revealed that A, running on average 6214 rev/day, expended approximately 64 kJ/day more than S. This they compensated for by increasing their food intake by 6 g/day (70 kJ/day). Over the estrous cycle wheel running was maximal at proestrus and minimal at metestrus-the reverse trend intake was observed. This cyclic difference in energy balance between metestrus and proestrus was estimated to be equivalent to 23% of the ''maintenance'' requirement. Thus voluntary activity bears a marked impact on day to day energy balance but has little effect in the long-term since in the female rat intake is precisely regulated to meet expenditure.