Recent applications of the 1,2-carbon atom migration strategy in complex natural product total synthesis
Recent applications of the 1,2-carbon atom migration strategy in complex natural product total synthesis
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1,2-碳原子迁移策略在复杂天然产物全合成中的最新应用
DOI：
10.1039/c6cs00935b
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发表时间：
2017
影响因子：
46.2
通讯作者：
Wang Shao-Hua
中科院分区：
文献类型：
--
作者：
Zhang Xiao-Ming;Tu Yong-Qiang;Zhang Fu-Min;Chen Zhi-Hua;Wang Shao-Hua
1，2-碳原子重排作为一种指导性的策略在复杂分子组装中得到了广泛的应用。由于它需要两个相邻原子之间的碳-碳或碳-杂原子键迁移，这种类型的反应能够通过分子骨架重组产生结构复杂性。这篇评论将集中在最近的就业这一战略在天然产物的全合成，突出了特殊的效用，这种合成方法在复杂的碳环，杂环或结构复杂的图案从合成更容易的前体的建设。
1,2-Carbon atom rearrangement has been broadly applied as a guiding strategy in complex molecule assembly. As it entails the carbon–carbon or carbon–heteroatom bond migration between two vicinal atoms, this type of reaction is capable of generating structural complexity through a molecular skeletal reorganization. This review will focus on recent employment of this strategy in the total synthesis of natural products, highlighting the exceptional utility of such synthetic methodologies in the construction of intricate carbocycles, heterocycles or structurally complex motifs from synthetically more accessible precursors.