Spontaneous brain activity, graph metrics, and head motion related to prospective post-traumatic stress disorder trauma-focused therapy response.
Spontaneous brain activity, graph metrics, and head motion related to prospective post-traumatic stress disorder trauma-focused therapy response.
复制标题
DOI：
10.3389/fnhum.2022.730745
复制
发表时间：
2022
影响因子：
2.9
通讯作者：
中科院分区：
文献类型：
--
作者：
创伤后应激障碍（PTSD）的创伤心理治疗对大约一半的患者有效。研究与前瞻性治疗反应相关的生物系统对于深入了解使患者易于成功干预的机制非常重要。我们研究了静息状态下的自发脑活动、脑网络特征和头部运动是否与未来的治疗成功相关。在治疗开始时，从46名患有PTSD的退伍军人中获得功能性磁共振成像扫描。心理治疗包括创伤集中认知行为疗法（tf-CBT）、眼动脱敏和再加工（EMDR）或其组合。干预后，24例患者被归类为治疗反应者，22例为治疗抵抗者。使用低频波动幅度（ALFF）评估组间自发脑活动的差异，而使用最小生成树（MST）方法评估全球和区域脑网络特征。此外，还评估了扫描仪内头部运动。在应答组和非应答组之间没有观察到自发脑活动和全局网络特征的差异。应答组的右顶下小叶、右壳核和左上级顶小叶在网络中的位置较非应答组更为中心，而右背外侧前额叶、右额下回和左颞下回的位置较非应答组更为中心。此外，应答者的头部运动较少。这些结果表明，涉及执行功能，注意力和动作过程，学习和视觉对象处理的领域与退伍军人的预期PTSD治疗反应有关。此外，这些发现表明，不自主的微运动可能与未来的治疗成功有关。
Trauma-focused psychotherapy for post-traumatic stress disorder (PTSD) is effective in about half of all patients. Investigating biological systems related to prospective treatment response is important to gain insight in mechanisms predisposing patients for successful intervention. We studied if spontaneous brain activity, brain network characteristics and head motion during the resting state are associated with future treatment success. Functional magnetic resonance imaging scans were acquired from 46 veterans with PTSD around the start of treatment. Psychotherapy consisted of trauma-focused cognitive behavioral therapy (tf-CBT), eye movement desensitization and reprocessing (EMDR), or a combination thereof. After intervention, 24 patients were classified as treatment responders and 22 as treatment resistant. Differences between groups in spontaneous brain activity were evaluated using amplitude of low-frequency fluctuations (ALFF), while global and regional brain network characteristics were assessed using a minimum spanning tree (MST) approach. In addition, in-scanner head motion was assessed. No differences in spontaneous brain activity and global network characteristics were observed between the responder and non-responder group. The right inferior parietal lobule, right putamen and left superior parietal lobule had a more central position in the network in the responder group compared to the non-responder group, while the right dorsolateral prefrontal cortex (DLPFC), right inferior frontal gyrus and left inferior temporal gyrus had a less central position. In addition, responders showed less head motion. These results show that areas involved in executive functioning, attentional and action processes, learning, and visual-object processing, are related to prospective PTSD treatment response in veterans. In addition, these findings suggest that involuntary micromovements may be related to future treatment success.
登录
查看更多内容
DOI：
10.3758/bf03203630
发表时间：
1996-02-01
期刊：
BEHAVIOR RESEARCH METHODS INSTRUMENTS & COMPUTERS
影响因子：
--
作者：
Erdfelder, E;Faul, F;Buchner, A
通讯作者：
Buchner, A
人脑网络组图谱：基于连接架构的新大脑图谱
DOI：
10.1093/cercor/bhw157
发表时间：
2016-08
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Fan L;Li H;Zhuo J;Zhang Y;Wang J;Chen L;Yang Z;Chu C;Xie S;Laird AR;Fox PT;Eickhoff SB;Yu C;Jiang T
通讯作者：
Jiang T
影响因子：
3.2
作者：
Gargouri F;Kallel F;Delphine S;Ben Hamida A;Lehéricy S;Valabregue R
通讯作者：
Valabregue R
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
基于最小生成树分析的多特征融合fMRI分类方法
影响因子：
2.3
作者：
Guo, Hao;Yan, Pengpeng;Xiang, Jie
通讯作者：
Xiang, Jie