Heart Failure With Normal Left Ventricular Ejection Fraction
Heart Failure With Normal Left Ventricular Ejection Fraction
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DOI：
10.1016/j.jacc.2008.12.007
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发表时间：
2009-03-17
影响因子：
24
通讯作者：
Kaye, David M.
中科院分区：
文献类型：
--
作者：
Maeder, Micha T.;Kaye, David M.
据估计，大约50%的心力衰竭人群具有正常的左心室射血分数，这是一种广泛称为心力衰竭伴正常左心室射血分数（HFNEF）的复合体。虽然这些患者在流行病学研究和临床试验中被认为是一个单一的患者群体，但有限的更详细的研究表明HFNEF患者是一个非常异质的群体，具有许多关键的病理生理机制。这篇综述总结并批判性分析了HFNEF的病理生理学的现有数据，将其与最近开发的诊断算法相结合。我们评估了常用的超声心动图测量和生物标志物的效用，并将机制观察整合到潜在的未来治疗方向中。（J Am科尔心脏病学杂志2009; 53：905-18）（C）2009年美国心脏病学会基金会
It is estimated that approximately 50% of the heart failure population has a normal left ventricular ejection fraction, a complex broadly referred to as heart failure with normal left ventricular ejection fraction (HFNEF). While these patients have been considered in epidemiologic studies and clinical trials to represent a single pool of patients, limited more detailed studies indicate that HFNEF patients are a very heterogeneous group, with a number of key pathophysiologic mechanisms. This review summarizes and critically analyzes available data on the pathophysiology of HFNEF, placing it into context with a recently developed diagnostic algorithm. We evaluate the utility of commonly applied echocardiographic measures and biomarkers and integrate mechanistic observations into potential future therapeutic directions. (J Am Coll Cardiol 2009; 53: 905-18) (C) 2009 by the American College of Cardiology Foundation