Attentional performance of C57BL/6 and DBA/2 mice in the 5-choice serial reaction time task
Attentional performance of C57BL/6 and DBA/2 mice in the 5-choice serial reaction time task
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DOI：
10.1016/j.bbr.2006.02.019
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发表时间：
2006-06-30
影响因子：
2.7
通讯作者：
Sluyter, F.
中科院分区：
文献类型：
--
作者：
Patel, S.;Stolerman, I. P.;Sluyter, F.
C57 BL/6和DBA/2在5选择系列反应时任务中比较了与注意力和冲动性相关的性能差异。目的是检查小鼠的行为过程可能与人类的ADHD有关。一组雄性老鼠被训练在五个洞中随机出现的刺激光下戳鼻子;正确的反应用食物来加强。在训练期间，刺激持续时间（SD）从60秒逐渐减少到0.5秒。C5713 L/6和DBA/2小鼠在训练的早期阶段没有差异，此时注意力需求较低（SD为60、10或5秒）。随着任务要求的增加，出现了应变差异; C57 BL/6小鼠比DBA/2小鼠在2，1和0.5 s的刺激下更准确。DBA/2小鼠在SD为5、2、1和0.5s时，在间隔时间内也比C57 BL/6小鼠产生更多的预期（冲动）反应。两种小鼠都有执行任务的能力，但它们在表现水平上有显着差异。有人认为，准确性和预期反应的差异是密切相关的，菌株之间的主要差异可能是在冲动。(c)2006 Elsevier B. V.保留所有权利。
C57BL/6 and DBA/2 were compared in the 5-choice serial reaction time task for differences in performance related to attention and impulsivity. The goal was to examine behavioural processes in mice that may relate to ADHD in humans. Groups of male mice were trained to nose-poke in response to a stimulus light presented randomly in one of five holes; correct responses were reinforced with food. During training the stimulus duration (SD) was reduced progressively from 60 to 0.5 s. The C5713L/6 and DBA/2 mice did not differ during early stages of training when attentional demands were low (SD of 60, 10 or 5 s). As task demands increased, strain differences emerged; C57BL/6 mice were more accurate than DBA/2 mice with stimuli of 2, 1 and 0.5 s. DBA/2 mice also made more anticipatory (impulsive) responses during inter-tilal intervals than C57BL/6 mice at SD of 5, 2, 1 and 0.5 s. The ability to carry out the task was present in both strains of mice but they differed significantly in the levels of performance that were achieved. It is argued that the differences in accuracy and anticipatory responding were closely related and that the primary difference between the strains may be in impulsivity. (c) 2006 Elsevier B.V. All rights reserved.