Selective effects of experimental glaucoma on axonal transport by retinal ganglion cells to the dorsal lateral geniculate nucleus.
Selective effects of experimental glaucoma on axonal transport by retinal ganglion cells to the dorsal lateral geniculate nucleus.
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发表时间：
1991-04
影响因子：
4.4
通讯作者：
Lalir Dandona;Anita Hendricksoaf;H. Quigley
中科院分区：
文献类型：
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作者：
Lalir Dandona;Anita Hendricksoaf;H. Quigley
快速相轴突运输到背外侧膝状体核（dLGN）的放射自显影确定在7只猕猴眼睛慢性眼内压（IOP）升高，在4只眼睛急性IOP升高，和在3只眼睛正常的IOP。通过定性检查，慢性IOP升高的猴的dLGN的大细胞层的放射性标记比小细胞层的放射性标记减少更大。在选定的标本中的颗粒计数证实，在慢性IOP升高的猴子中，向大细胞层的转运少于向小细胞层的转运。这种选择性存在于轻度损伤的标本中，并随着神经节细胞损失的增加而增加。在急性IOP升高的猴中，定性评价表明dLGN层之间的转运无一致差异;通过颗粒计数，该组中的一只动物向小细胞层的转运少于向大细胞层的转运。从疾病的早期阶段开始，慢性实验性青光眼对投射到dLGN的大细胞层的神经节细胞造成优先损伤。
Rapid-phase axonal transport to the dorsal lateral geniculate nucleus (dLGN) was determined autoradiographically in seven macaque monkey eyes with chronic intraocular pressure (IOP) elevation, in four eyes with an acute IOP elevation, and in three eyes with normal IOP. The monkeys with chronic IOP elevation showed a greater decrease in radioactive labeling of the magnocellular layers of the dLGN than the parvocellular layers by qualitative examination. Grain counts in selected specimens confirmed that transport to the magnocellular layers was less than to the parvocellular layers in monkeys with chronic IOP elevation. This selectivity was present in mildly damaged specimens and increased with greater ganglion cell loss. In monkeys with acute IOP elevation, qualitative evaluation suggested no consistent difference in transport among the dLGN layers; one animal in this group had less transport to the parvocellular than to the magnocellular layers by grain counts. Starting in early stages of the disease, chronic experimental glaucoma causes preferential damage to the ganglion cells that project to the magnocellular layers of the dLGN.