Incidence and epidemiologic associations of corneal infiltrates with silicone hydrogel contact lenses.
Incidence and epidemiologic associations of corneal infiltrates with silicone hydrogel contact lenses.
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硅水凝胶隐形眼镜角膜浸润的发生率和流行病学关联。
DOI：
10.1097/icl.0b013e318271d3dc
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Chalmers,Robin
中科院分区：
文献类型：
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作者：
Szczotka-Flynn,Loretta;Chalmers,Robin
角膜接触镜相关性角膜浸润事件（CIE）是假定的无菌事件，其具有复杂的接触透镜配戴超过30年。有一致的证据表明，与低Dk水凝胶材料相比，硅水凝胶软性角膜接触镜的CIE风险增加了两倍。对于症状性事件，硅水凝胶长期配戴期间CIE的发生率范围为2%-6%，如果包括无症状事件，则为6%-25%。对于硅水凝胶的日常配戴，有症状事件的CIE发生率范围为2%-3%，包括无症状事件的CIE发生率范围为7%-20%。尽管使用硅水凝胶的CIE发生率增加，但对于许多患者而言，这些镜片的受益在很大程度上超过了该风险。使用硅水凝胶观察到的CIE的大多数风险因素与早期使用水凝胶镜片报告的CIE风险因素一致，例如透镜表面上的细菌生物负载和年轻等。限制细菌生物负载从皮肤转移到镜片、透镜盒并最终转移到眼睛是预防所有透镜类型CIE的明显进步。
Contact lens–associated corneal infiltrative events (CIEs) are presumed sterile events that have complicated contact lens wear for more than 30 years. There is consistent evidence that silicone hydrogel soft contact lenses increase CIE risk by twofold compared with low Dk hydrogel materials. The incidence of CIEs during silicone hydrogel extended wear ranges from 2% to 6% for symptomatic events and from 6% to 25% when asymptomatic events are included. For daily wear, with silicone hydrogels, the incidence of CIEs ranges from 2% to 3% for symptomatic events and from 7% to 20% when asymptomatic events are included. Despite the increased rate of CIEs with silicone hydrogels, the benefits of these lenses largely outweigh this risk for many patients. Most risk factors for CIEs observed with silicone hydrogels are consistent with CIE risk factors reported earlier with hydrogel lenses, such as bacterial bioburden on lens surfaces, and young age among others. Limiting the transfer of bacterial bioburden from the skin to lenses, lens cases and eventually to the eye is an obvious step forward for the prevention of CIEs across all lens types.