WEIGHT-BEARING EXERCISE TRAINING AND LUMBAR BONE-MINERAL CONTENT IN POSTMENOPAUSAL WOMEN
WEIGHT-BEARING EXERCISE TRAINING AND LUMBAR BONE-MINERAL CONTENT IN POSTMENOPAUSAL WOMEN
复制标题
DOI：
10.7326/0003-4819-108-6-824
复制
发表时间：
1988-06-01
影响因子：
39.2
通讯作者：
BIRGE, SJ
中科院分区：
文献类型：
--
作者：
DALSKY, GP;STOCKE, KS;BIRGE, SJ
研究目的：评估负重运动训练和随后停止训练对绝经后妇女腰椎骨矿含量的影响。设计：非随机、对照、短期（9个月）试验和长期（22个月）运动训练和停训（13个月）。单位：一所大学医学院的应用生理学教研室。患者：35名健康、久坐的绝经后女性，年龄55 - 70岁。所有女性都完成了研究。运动训练的依从性为90%。干预措施：所有女性每天服用1500 mg钙。运动组每周3次，以最大摄氧量的70%~ 90%进行负重运动（步行、慢跑、爬楼梯），每次50 ~ 60 min。测量和主要结果：短期训练后，骨矿物质含量较基线增加5.2%（95%置信区间[CI]，2.0%至8.4%; P = 0.0037），而对照组无变化（-1.4%）。经过22个月的锻炼，长期训练组的骨矿物质含量为6.1%（95%CI，高于基线3.9%至8.3%; P = 0.0001）。活动减少13个月后，停止训练组的骨量比基线高1.1%。结论：负重运动导致骨矿物质含量显著高于基线水平，在老年绝经后妇女中持续训练可维持这一水平。随着负重运动的减少，骨量恢复到基线水平。需要进一步的研究来确定阈值运动处方，将产生显着增加骨量。
Study Objective: To assess the effect of weight-bearing exercise training and subsequent detraining on lumbar bone mineral content in postmenopausal women. Design: Non-randomized, controlled, short-term (9 months) trial and long-term (22 months) exercise training and detraining (13 months). Setting: Section of applied physiology at a university school of medicine. Patients: Thirty-five healthy, sedentary postmenopausal women, 55 to 70 years old. All women completed the study. There was 90% compliance with exercise training. Interventions: All women were given calcium, 1500 mg daily. The exercise group did weight-bearing exercise (walking, jogging, stair climbing) at 70% to 90% of maximal oxygen uptake capacity for 50 to 60 min, 3 times weekly. Measurements and Main Results: Bone mineral content increased 5.2% (95% confidence interval [CI], 2.0% to 8.4%; P = 0.0037) above baseline after short-term training whereas there was no change (-1.4%) in the control group. After 22 months of exercise, bone mineral content was 6.1% (95% Cl, 3.9% to 8.3% above baseline; P = 0.0001) in the long-term training group. After 13 months of decreased activity, bone mass was 1.1% above baseline in the detraining group. Conclusions: Weight bearing exercise led to significant increases above baseline in bone mineral content which were maintained with continued training in older, postmenopausal women. With reduced weight-bearing exercise, bone mass reverted to baseline levels. Further studies are needed to determine the threshold exercise prescription that will produce significant increases in bone mass.