Injectable biopolymers enhance angiogenesis after myocardial infarction
Injectable biopolymers enhance angiogenesis after myocardial infarction
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DOI：
10.1089/ten.2005.11.1860
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发表时间：
2005-11-01
影响因子：
--
通讯作者：
Lee, RJ
中科院分区：
文献类型：
--
作者：
Huang, NF;Yu, JS;Lee, RJ
心肌梗死后修复缺血心肌的新策略包括使用三维聚合物支架。进行了一项比较研究，以评估纤维蛋白，胶原蛋白I，和基质胶作为可注射的生物聚合物用于心肌梗死后修复的治疗潜力。使用大鼠模型的左冠状动脉闭塞，然后再灌注，局部注射的生物聚合物到梗死区产生显着更高水平的毛细血管形成时，与生理盐水对照组相比，在5周治疗后。然而，血管生成的程度在生物聚合物之间没有显著差异。此外，与对照组相比，胶原生物聚合物显著增强了肌成纤维细胞向梗死区域的浸润。这项研究的结果突出了这些生物聚合物作为可注射支架或细胞递送载体在梗死后向梗死区的潜在临床益处。
Novel strategies by which to repair ischemic myocardium after myocardial infarction include the use of three-dimensional polymer scaffolds. A comparative study was carried out to assess the therapeutic potential of fibrin, collagen I, and Matrigel as injectable biopolymers for repair after myocardial infarction. Using a rat model of left coronary artery occlusion followed by reperfusion, local injection of the biopolymers into the infarct zone yielded significantly higher levels of capillary formation, when compared with the saline control group, at 5 weeks posttreatment. However, the degree of angiogenesis was not significantly different among the biopolymers. In addition, the collagen biopolymer significantly enhanced infiltration of myofibroblasts into the infarct area when compared with the control group. The results of this study highlight the potential clinical benefit of these biopolymers as injectable scaffolds or cell delivery vehicles to the infarct zone after infarction.