Effects of ginseng soluble dietary fiber on serum antioxidant status, immune factor levels and cecal health in healthy rats
Effects of ginseng soluble dietary fiber on serum antioxidant status, immune factor levels and cecal health in healthy rats
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DOI：
10.1016/j.foodchem.2021.130641
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发表时间：
2021-07-26
期刊：
影响因子：
8.8
通讯作者：
Sun, Yinshi
中科院分区：
文献类型：
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作者：
Hua, Mei;Liu, Zhengbo;Sun, Yinshi
人参水溶性膳食纤维（ginseng-SDF）作为人参的重要成分，其体内功效尚未完全显现。为了探索这些益处，健康大鼠通过管饲法给予人参-SDF（200、400和800 mg/kg体重/天）15天。结果表明，人参可溶性膳食纤维能显著提高大鼠的生长性能和血清抗氧化水平。人参-SDF组的胰岛素样生长因子（IGF-1和IGF-2）和免疫球蛋白（伊加，IgM和IgG）水平升高。与K组相比，高剂量人参SDF显著提高了盲肠丁酸的比例。人参SDF能增加盲肠菌群中厚壁菌门的数量，促进乳酸菌等益生菌和纤维素分解菌如瘤胃球菌、梭菌等的增殖。这些改变的微生物区系与生长性能、抗氧化状态和免疫球蛋白指数相关。以上结果提示，人参SDF对大鼠生长发育、氧化免疫水平和盲肠健康有积极作用。
As an important component of ginseng, the in vivo benefits of ginseng water-soluble dietary fiber (ginseng-SDF) have not been fully revealed. To explore these benefits, healthy rats were given ginseng-SDF (200, 400, and 800 mg/kg body weight/day) by gavage for 15 days. The results showed that ginseng-SDF significantly improved the rats' growth performance and serum antioxidant status. Insulin-like growth factor (IGF-1 and IGF-2) and immunoglobulin (IgA, IgM, and IgG) levels in the ginseng-SDF groups were increased. High-dose ginseng-SDF significantly increased the cecal butyric acid proportion compared with the K group. Ginseng-SDF increased the abundance of Firmicutes and promoted the proliferation of probiotics such as Lactobacillus, and cellulose decomposers such as Ruminococcus and Clostridium in cecal micmflora. These altered microflora were correlated with growth performance, antioxidant status and immunoglobulin indexes. The above results suggested that ginseng-SDF might have positive effects on growth, oxidative-immune levels and cecal health in rats.