Self-reported hepatitis C virus antibody status and risk behavior in young injectors
Self-reported hepatitis C virus antibody status and risk behavior in young injectors
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DOI：
10.1177/003335490612100611
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发表时间：
2006-11-01
影响因子：
3.3
通讯作者：
Garfein, Richard S.
中科院分区：
文献类型：
--
作者：
Hagan, Holly;Campbell, Jennifer;Garfein, Richard S.
目标。本研究旨在评估注射吸毒者（IDUs）自报丙型肝炎病毒（HCV）抗体（anti-HCV）血清状态的准确性，并探讨自报丙型肝炎病毒抗体（anti-HCV）血清状态是否与近期注射危险行为相关。在美国的五个城市（巴尔的摩、芝加哥、洛杉矶、纽约和西雅图），招募了3004名15至30岁的注射吸毒者进行基线访谈，以确定是否有资格参加行为干预的随机对照试验。进行HIV和HCV抗体检测，并通过计算机管理的音频自我访谈收集受试者数据（如人口统计学、药物和性危险行为、HIV和HCV检测史）。将前三个月的危险行为与自我报告的抗hcv血清状态进行比较。该样本中年轻注射吸毒者的抗- hcv患病率为34.1%。该样本中72%的抗HCV阳性和46%的抗HCV阴性注射者不知道自己的HCV血清状态。药物治疗或针头交换使用与HCV血清状态意识的提高有关。知道自己血清状况的抗丙型肝炎病毒阴性注射吸毒者比不知道自己状况的注射吸毒者更不可能使用另一个注射吸毒者使用的注射器进行注射或共用棉花过滤药物溶液。了解自己的抗- hcv阳性状态与更安全的注射行为无关。本研究中抗hcv阳性IDUs很少知道自己的血清状态。这一人群显然需要扩大丙型肝炎病毒筛查和高质量咨询，以促进慢性丙型肝炎病毒感染注射吸毒者的健康，并降低易感染或传播丙型肝炎病毒的注射者的风险。
Objective. This study was conducted to assess the accuracy of self-reported hepatitis C virus (HCV) antibody (anti-HCV) serostatus in injection drug users (IDUs), and examine whether self-reported anti-HCV serostatus was associated with recent injection risk behavior.Methods. In five U.S. cities (Baltimore, Chicago, Los Angeles, New York, and Seattle), 3,004 IDUs from 15 to 30 years old were recruited for a baseline interview to determine eligibility for a randomized controlled trial of a behavioral intervention. HIV and HCV antibody testing were performed, and subject data (e.g., demographics, drug and sexual risk behavior, and history of HIV and HCV testing) were collected via audio computer-administered self-interview. Risk behavior during the previous three months was compared to self-reported anti-HCV serostatus.Results. Anti-HCV prevalence in this sample of young IDUs was 34.1%. Seventy-two percent of anti-HCV-positive and 46% of anti-HCV-negative IDUs in this sample were not aware of their HCV serostatus. Drug treatment or needle exchange use was associated with increased awareness of HCV serostatus. Anti-HCV-negative IDUs who knew their serostatus were less likely than those unaware of their status to inject with a syringe used by another IDU or to share cottons to filter drug solutions. Knowledge of one's positive anti-HCV status was not associated with safer injection practices.Conclusions. Few anti-HCV-positive IDUs in this study were aware of their serostatus. Expanded availability of HCV screening with high quality counseling is clearly needed for this population to promote the health of chronically HCV-infected IDUs and to decrease risk among injectors susceptible to acquiring or transmitting HCV.