Association between hepatitis C virus seropositivity, carotid-artery plaque, and intima-media thickening
Association between hepatitis C virus seropositivity, carotid-artery plaque, and intima-media thickening
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DOI：
10.1016/s0140-6736(02)07339-7
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发表时间：
2002-01-12
期刊：
影响因子：
168.9
通讯作者：
Yamakado, M
中科院分区：
文献类型：
--
作者：
Ishizaka, N;Ishizaka, Y;Yamakado, M
我们通过分析接受一般健康筛查测试的个体的横截面数据，研究了丙型肝炎病毒（HCV）阳性与颈动脉斑块和颈动脉内膜中层增厚之间的关系。在 4784 名登记者中，104 名 (2.2%) 的 HCV 血清呈阳性。调整混杂危险因素后，发现 HCV 血清阳性与颈动脉斑块风险增加相关（比值比 1.92 [95% Cl 1.56-2.38]，p = 0.002）和颈动脉内膜中层增厚（2.85 [2.28-3.57]，p < 0.0001）。这些发现表明慢性丙型肝炎在颈动脉重塑的发病机制中可能发挥作用。
We Investigated the relation between positivity for hepatitis C virus (HCV) and carotid-artery plaque and carotid intima-media thickening by analysing cross-sectional data of Individuals undergoing a general health screening test. Of 4784 individuals enrolled, 104 (2.2%) were seropositive for HCV. After adjustment for confounding risk factors, HCV seropositivity was found to be associated with an increased risk of carotid-artery plaque (odds ratio 1.92 [95% Cl 1.56-2.38], p = 0.002) and carotid intima-media thickening (2.85 [2.28-3.57], p < 0.0001). These findings suggest a possible role for chronic hepatitis C in the pathogenesis of carotid arterial remodelling.