Two novel aromatic valerenane-type sesquiterpenes from the Chinese green alga Caulerpa taxifolia
Two novel aromatic valerenane-type sesquiterpenes from the Chinese green alga Caulerpa taxifolia
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DOI：
10.1016/j.bmcl.2006.02.074
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发表时间：
2006-06-01
影响因子：
2.7
通讯作者：
Shen, X
中科院分区：
文献类型：
--
作者：
Mao, SC;Guo, YW;Shen, X
从中国绿藻Caulerpa axifolia(Vahl)C.Agardh中分离得到两个新的倍半萜化合物A(2)和B(3)，它们具有罕见的芳香族戊烯烷型碳骨架，以及一个已知的代谢物--caulerpin(4)。通过广泛的光谱分析，阐明了它们的结构和相关的立体化学。对化合物2-4对hPTP1B的抑制活性进行了评价，结果表明只有化合物4具有较强的PTP1B抑制活性，其IC50值为3.77µM(C)2006爱思唯尔有限公司。
Caulerpal A (2) and B (3), two novel sesquiterpenes possessing an uncommon aromatic valerenane-type carbon skeleton, along with one known metabolite, caulerpin (4), have been isolated from the Chinese green alga Caulerpa taxifolia (Vahl) C. Agardh. Their structures and relative stereochemistry were elucidated on the basis of extensive spectroscopic analysis. Compounds 2-4 were evaluated for their inhibitory activity against hPTP1B and the result showed that only compound 4 had a strong PTP1B inhibitory activity with an IC50 value of 3.77 mu M. (c) 2006 Elsevier Ltd. All rights reserved.