Serum Fatty Acid and Risk of Coronary Artery Disease - Circulatory Risk in Communities Study (CIRCS) -
Serum Fatty Acid and Risk of Coronary Artery Disease - Circulatory Risk in Communities Study (CIRCS) -
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DOI：
10.1253/circj.cj-18-0240
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发表时间：
2018-12-01
影响因子：
3.3
通讯作者：
Iso, Hiroyasu
中科院分区：
文献类型：
--
作者：
Chei, Choy-Lye;Yamagishi, Kazumasa;Iso, Hiroyasu
背景：很少有前瞻性研究探讨脂肪酸（FA）与CAD风险之间的关系。对每个个体血清FA作为冠状动脉风险或保护因素的作用的理解仍然有限。本研究的目的是调查哪些血清FA与日本受试者的CAD发病率相关。方法和结果：一项前瞻性巢式病例对照研究，40-85岁的日本受试者进行了使用冷冻血清样本收集12，840名参与者参加了1984年至1998年1个社区和1989年至1997年2个其他社区的心血管风险调查。每例病例中有3名对照受试者，按性别、年龄、社区、血清储存年份和空腹状态进行匹配。到2005年，我们已经确定了152例CAD事件病例。平均n-3-多不饱和和饱和脂肪酸没有显着差异的情况下和对照组，而平均n-6-多不饱和脂肪酸是较高的对照组与病例相比。最高与最低四分位数的肉豆蔻酸（14：0）、棕榈酸（16：0）、棕榈油酸（16：1）和亚油酸（18：2）的CAD多变量OR为2.8（95% CI：1.5-5.2），2.7（95% CI：1.4-5.5），3.2（95% CI：1.7-6.1）和0.4（95% CI：0.2-0.7）。高血清肉豆蔻酸、棕榈酸和棕榈油酸对冠心病的危险性有不利影响，高血清亚油酸对冠心病的危险性有保护作用。
Background: Few prospective studies have explored the association between fatty acids (FA) and risk of CAD. Understanding of the role of each individual serum FA as a coronary risk or protective factor is still limited. The aim was to investigate which serum FA are associated with the incidence of CAD in Japanese subjects.Methods and Results: A prospective nested case-control study of 40-85-year-old Japanese subjects was undertaken using frozen serum samples collected from 12,840 participants who participated in cardiovascular risk surveys from 1984 to 1998 for 1 community and 1989-1997 for 2 other communities. Three control subjects per case were matched by sex, age, community, year of serum storage and fasting status. By 2005 we had identified 152 incident cases of CAD. Mean n-3-polyunsaturated and saturated FA did not differ between cases and controls, while mean n-6-polyunsaturated FA was higher in controls compared with cases. The multivariable OR of CAD for the highest vs. lowest quartiles of miristic acid (14: 0), palmitic acid (16: 0), palmitoleic acid (16: 1), and linoleic acid (18: 2) were 2.8 (95% CI: 1.5-5.2), 2.7 (95% CI: 1.4-5.5), 3.2 (95% CI: 1.7-6.1) and 0.4 (95% CI: 0.2-0.7), respectively.Conclusions: High serum miristic acid, palmitic acid and palmitoleic acid have an adverse effect, and high serum linoleic acid had a protective effect, on the risk of CAD.