Inflammatory cytokines and ischemic stroke risk The REGARDS cohort
Inflammatory cytokines and ischemic stroke risk The REGARDS cohort
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DOI：
10.1212/wnl.0000000000007416
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发表时间：
2019-05-14
期刊：
影响因子：
9.9
通讯作者：
Cushman, Mary
中科院分区：
文献类型：
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作者：
Jenny, Nancy Swords;Callas, Peter W.;Cushman, Mary
我们研究了循环白细胞介素（IL）-6，IL-8和IL-10浓度和缺血性中风的发病风险在birthorax队列，并确定这些细胞因子介导的中风发病率的种族差异影响黑人population.MethodsThe中风研究的地理和种族差异的原因招募了30,237名黑人和白色男性和女性年龄= 45在2003-2007年。我们测量基线IL-6，IL-8和IL-10的情况下，队列研究的557名参与者与事件中风超过5.4年和951名参与者在一个队列sample.ResultsIL-6，但不是IL-8或IL-10，是较高的情况下，队列样本相比（平均4.5与3.7 ng/mL; p < 0.001）。只有IL-6与卒中危险因素相关。调整年龄、性别和种族后，IL-6最高四分位数与最低四分位数发生中风的风险比（HR; 95%置信区间）为2.4（1.6-3.4）。IL-8和IL-10的最高与最低四分位数的HR分别为1.5（1.0-2.1）和1.4（1.0-1.9）。在对卒中风险因素进行额外调整后，只有较高的IL-6仍与卒中风险相关（HR 2.0; 1.2-3.1）。协会并没有因种族而异。调解分析表明，IL-6介导的黑-白差距中风的风险，但调解是通过IL-6协会与中风risk factors.ConclusionsIn this birthday population based sample，IL-6是强烈相关的风险事件中风和介导的种族差异中风通过炎症的影响危险因素。进一步研究IL-6测量在卒中风险评估中的临床效用将是有益的。
ObjectiveWe studied circulating interleukin (IL)-6, IL-8, and IL-10 concentrations and incident ischemic stroke risk in a biracial cohort, and determined if these cytokines mediated the racial disparity in stroke incidence affecting the black population.MethodsThe Reasons for Geographic and Racial Differences in Stroke study enrolled 30,237 black and white men and women age = 45 in 2003-2007. We measured baseline IL-6, IL-8, and IL-10 in a case-cohort study of 557 participants with incident stroke over 5.4 years and 951 participants in a cohort sample.ResultsIL-6, but not IL-8 or IL-10, was higher in cases compared to the cohort sample (mean 4.5 vs 3.7 ng/mL; p < 0.001). Only IL-6 was associated with stroke risk factors. Adjusting for age, sex, and race, the hazard ratio (HR; 95% confidence interval) for incident stroke for the highest vs lowest quartile of IL-6 was 2.4 (1.6-3.4). HRs for the highest vs lowest quartiles of IL-8 and IL-10 were 1.5 (1.0-2.1) and 1.4 (1.0-1.9), respectively. After additional adjustment for stroke risk factors, only higher IL-6 remained associated with stroke risk (HR 2.0; 1.2-3.1). Associations did not differ by race. Mediation analyses showed that IL-6 mediated the black-white disparity in stroke risk, but mediation was via IL-6 associations with stroke risk factors.ConclusionsIn this biracial population-based sample, IL-6 was strongly associated with risk of incident stroke and mediated the racial disparity in stroke via inflammatory effects of risk factors. Further study on the clinical utility of IL-6 measurement in stroke risk assessment would be helpful.