Radiation-induced grafting of acrylic acid onto expanded poly(tetrafluoroethylene) membranes
Radiation-induced grafting of acrylic acid onto expanded poly(tetrafluoroethylene) membranes
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DOI：
10.1016/j.polymer.2012.10.042
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发表时间：
2012-12-07
期刊：
影响因子：
4.6
通讯作者：
Grondahl, Lisbeth
中科院分区：
文献类型：
--
作者：
Hidzir, Norsyahidah Mohd;Hill, David J. T.;Grondahl, Lisbeth
膨体聚四氟乙烯（ePTFE）目前应用于面部重建手术。在软组织替代物中使用 ePTFE 膜的一项要求是与周围骨骼建立良好的粘合界面。然而，ePTFE 被归类为生物惰性，因此缺乏仿生特性，可能导致骨植入物界面的骨整合不良。因此，在当前的研究中，使用辐射诱导丙烯酸（AA）接枝将官能团引入到聚合物表面，接枝率高达 40%。这导致疏水性降低（接触角从 116 度降低到 92 度）。 XPS 显示接枝的 PAA 是高度交联的。评估了接枝条件（剂量、单体浓度以及溶剂）对接枝结果的影响。对丙烯酸叔丁酯 (tBA) 的接枝进行了研究，但接枝率较低，并且表明这不受接枝过程中使用的溶剂的影响。 AA 接枝膜的机械性能发生显着变化，并且取决于测试条件（湿或干）。 Crown 版权所有 (C) 2012 由 Elsevier Ltd 出版。保留所有权利。
Expanded poly(tetrafluoroethylene) (ePTFE) is currently being applied in facial reconstruction surgery. One requirement for the use of ePTFE membranes in soft tissue replacements is establishment of a well-bonded interface with the surrounding bone. However, ePTFE is classified as bioinert, thus lacking in biomimetic properties which may result in poor osseointegration at the bone implant interface. Thus, the introduction of functional groups onto the polymer surface was carried out in the current study using radiation induced grafting of acrylic acid (AA) yielding graft yields of up to 40%. This resulted in reducing the hydrophobicity (advancing contact angle reduced from 116 to 92 degrees). XPS revealed that the grafted PAA was highly crosslinked. The effects of grafting conditions (dose, monomer concentration, as well as solvent) on the grafting outcome were evaluated. Grafting of tertbutyl acrylate (tBA) was investigated but low graft yields were obtained and this was shown to be unaffected by the solvent used during the grafting process. The mechanical properties of the AA grafted membranes were altered significantly and were dependent on the testing conditions (wet or dry). Crown Copyright (C) 2012 Published by Elsevier Ltd. All rights reserved.