The role of BRD7 in embryo development and glucose metabolism.
The role of BRD7 in embryo development and glucose metabolism.
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DOI：
10.1111/jcmm.12907
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发表时间：
2016-08
影响因子：
5.3
通讯作者：
Park SW
中科院分区：
文献类型：
--
作者：
Kim Y;Andrés Salazar Hernández M;Herrema H;Delibasi T;Park SW
含溴结构域蛋白 7 (BRD7) 是含溴结构域蛋白家族的一员，其功能与多种疾病有关。我们之前已经证明 BRD7 在代谢过程中发挥作用。然而，BRD7 缺陷对葡萄糖代谢的影响及其在体内的作用尚未完全揭示。在这里，我们报告了 BRD7 在胚胎发育过程中的重要作用。 BRD7纯合子小鼠在妊娠中期导致胚胎死亡。纯合 BRD7 敲除 (KO) 小鼠表现出发育迟缓，最终所有 BRD7 KO 胚胎在 E16.5 之前都在子宫内死亡。 Brd7 基因的部分敲低显示葡萄糖代谢的轻微变化。
Bromodomain‐containing protein 7 (BRD7) is a member of bromodomain‐containing protein family and its function has been implicated in several diseases. We have previously shown that BRD7 plays a role in metabolic processes. However, the effect of BRD7 deficiency in glucose metabolism and its role in in vivo have not been fully revealed. Here, we report the essential role of BRD7 during embryo development. Mice homozygous for BRD7 led to embryonic lethality at mid‐gestation. Homozygous BRD7 knockout (KO) mice showed retardation in development, and eventually all BRD7 KO embryos died in utero prior to E16.5. Partial knockdown of Brd7 gene displayed mild changes in glucose metabolism.