Predictive validity of the extinction/reinstatement model of drug craving
Predictive validity of the extinction/reinstatement model of drug craving
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DOI：
10.1007/s002130050496
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发表时间：
1998-01-01
影响因子：
3.4
通讯作者：
Neisewander, JL
中科院分区：
文献类型：
--
作者：
Fuchs, RA;Tran-Nguyen, LTL;Neisewander, JL
评估慢性去甲基丙咪嗪 (DMI) 治疗对可卡因激励动机测量的影响，以研究药物渴望消退/恢复模型的预测有效性。训练大鼠对可卡因输注（每 0.1 毫升静脉注射 0.75 毫克/千克）做出反应，或在每天 3 小时的疗程中接受轭盐水输注。输液呈现出一种光和色调。自我给药训练后，每组每天注射生理盐水或 DMI（10 mg/kg，IP），持续 21 天，退出自我给药方案。在戒断第 12-21 天，让大鼠在没有可卡因强化的情况下做出反应（灭绝阶段）。达到 1 小时无反应的消除标准后，重复提供可卡因配对刺激以恢复反应（恢复阶段）。在对照组中，DMI 治疗没有改变任一测试阶段的反应，但增加了消退阶段的反应潜伏期。相比之下，可卡因组的 DMI 治疗在两个测试阶段均降低了反应并增加了反应潜伏期，并减少了消退阶段的消退潜伏期。总体而言，DMI 的效果与可卡因激励动机的减少是一致的，这为毒品渴望消失/恢复模型的预测有效性提供了支持。
The effects of chronic desmethylimipramine (DMI) treatment on measures of incentive motivation for cocaine were assessed in order to investigate the predictive validity of the extinction/reinstatement model of drug craving. Rats were trained to respond for cocaine infusions (0.75 mg/kg per 0.1 ml IV) or received yoked-saline infusions during daily 3-h sessions. A light and tone were presented with the infusions. Following self-administration training, each group received daily injections of either saline or DMI (10 mg/kg, IP) for 21 days of withdrawal from the self-administration regimen. On days 12-21 of withdrawal, rats were allowed to respond in the absence of cocaine reinforcement (extinction phase). After reaching an extinction criterion of no responses for 1 h, the cocaine-paired stimuli were repeatedly presented to reinstate responding (reinstatement phase). In the control group, DMI treatment did not alter responding during either test phase, but increased the response latency during the extinction phase. In contrast, DMI treatment in the cocaine group decreased responding and increased the response latency during both test phases, and decreased the extinction latency during the extinction phase. Overall, the effects of DMI were consistent with a reduction of incentive motivation for cocaine, lending support for the predictive validity of the extinction/reinstatement model of drug craving.