Shiga Toxin-Producing Escherichia coli (STEC)
Shiga Toxin-Producing Escherichia coli (STEC)
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DOI：
10.1016/j.cll.2009.11.001
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发表时间：
2010-03-01
影响因子：
1.7
通讯作者：
Hunt, John M.
中科院分区：
文献类型：
--
作者：
Hunt, John M.
产滋贺毒素大肠埃希菌（STEC）是世界范围内重要的肠道病原体，可引起腹泻伴或不伴肉眼可见的血液和溶血性尿毒症综合征。STEC在产肠出血性大肠杆菌卡利中是独特的，其产生滋贺毒素1型和2型，这是引起血性腹泻和溶血性尿毒综合征的毒力因子。牛和其他反刍动物是STEC的天然储存库，因为它们的正常肠道植物群。人类因食用被牛粪污染的食物而感染。STEC感染的早期诊断很重要，因为使用抗菌药物治疗STEC是禁忌症，如果发生肾衰竭，则需要加强支持性护理。
Shiga toxin producing Escherichia coli (STEC) are important enteric pathogens worldwide, causing diarrhea with or without blood visibly present and hemolytic uremic syndrome. STEC are unique among diarrheogenic E cali in producing Shiga toxin type 1 and type 2, the virulence factors responsible for bloody diarrhea and hemolytic uremic syndrome. Cattle and other ruminants are the natural reservoir of STEC as their normal intestinal flora. Humans become infected by consumption of foods contaminated with cattle feces. Early diagnosis of STEC infection is important because of the contraindication for treating STEC using antimicrobial agents, and the intense supportive care needed if renal failure occurs.