Effects of beraprost sodium and insulin on the electroretinogram, nerve conduction, and nerve blood flow in rats with streptozotocin-induced diabetes
Effects of beraprost sodium and insulin on the electroretinogram, nerve conduction, and nerve blood flow in rats with streptozotocin-induced diabetes
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DOI：
10.2337/diabetes.45.3.361
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发表时间：
1996-03-01
期刊：
影响因子：
7.7
通讯作者：
Sakamoto, N
中科院分区：
文献类型：
--
作者：
Hotta, N;Koh, N;Sakamoto, N
前列环素类似物，贝前列素钠，对视网膜电图，运动神经传导速度和神经血流量的影响进行了测定与链脲佐菌素诱导的糖尿病大鼠，并与胰岛素的效果进行了比较。贝前列素钠（0.01 mg . kg（-1）。d（-1），持续8周）显着缩短糖尿病大鼠视网膜电图b波峰值潜伏期，增加尾神经传导速度，增加坐骨神经血流量（与未治疗的糖尿病大鼠相比，P < 0.0003、0.0001和0.0001）。这伴随着胸主动脉6-酮-前列腺素F-1 α含量的显著增加和坐骨神经cAMP含量的显著增加。贝前列素钠对坐骨神经和视网膜的山梨醇和果糖含量没有影响，但胰岛素（8-10 U/天）显著降低了这两个参数。这些发现表明贝前列素钠可能有助于预防视网膜和外周神经的血管和神经功能障碍。
The effect of a prostacyclin analog, beraprost sodium, on the electroretinogram, motor nerve conduction velocity, and nerve blood flow was determined in rats with streptozotocin-induced diabetes and was compared with the effect of insulin. Beraprost sodium (0.01 mg . kg(-1). day(-1) for 8 weeks) significantly shortened the peak latency of the electroretinogram b-wave, increased tail nerve conduction velocity, and increased sciatic nerve blood flow in diabetic rats (P < 0.0003, 0.0001, and 0.0001 vs. untreated diabetic rats, respectively). This was accompanied by a significant increase in the 6-keto-prostaglandin F-1 alpha content of the thoracic aorta and a marked increase in the cAMP content of the sciatic nerve. Beraprost sodium had no effect on the sorbitol and fructose contents of the sciatic nerve and retina, but insulin (8-10 U/day) significantly reduced both parameters. These findings suggest that beraprost sodium may be useful for prevention of vascular and neural dysfunction in the retina and peripheral nerve.