Lipopolysaccharide Increases Immune Activation and Alters T Cell Homeostasis in SHIVB'WHU Chronically Infected Chinese Rhesus Macaque.
Lipopolysaccharide Increases Immune Activation and Alters T Cell Homeostasis in SHIVB'WHU Chronically Infected Chinese Rhesus Macaque.
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DOI：
10.1155/2015/202738
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发表时间：
2015
影响因子：
4.1
通讯作者：
Zheng YT
中科院分区：
文献类型：
--
作者：
Zhang GH;Wu RD;Zheng HY;Zhang XL;Zhang MX;Tian RR;Liu GM;Pang W;Zheng YT
免疫激活在HIV的疾病进展中起着重要作用。微生物产物，特别是细菌脂多糖（LPS），有助于免疫激活。越来越多的证据表明，T淋巴细胞稳态破坏与免疫激活有关。然而，LPS影响免疫应答破坏的机制仍不完全清楚。本研究中，慢性SHIVB'WHU感染的中国恒河猴接受50 μg/kg体重的LPS。LPS给药通过提高病毒复制水平和活化T淋巴细胞影响病毒/宿主平衡。LPS诱导CD 8+幼稚T细胞的上调，并下调CD 4+和CD 8 + T效应记忆细胞的数量。下调的效应记忆细胞与较低频率的单功能和多功能细胞相关，并且在LPS刺激后在猴中观察到CD 4+和CD 8 + T细胞上的程序性细胞死亡-1（PD-1）表达上调。我们的数据提供了新的见解LPS在SHIV/HIV感染的免疫激活的功能。
Immune activation plays a significant role in the disease progression of HIV. Microbial products, especially bacterial lipopolysaccharide (LPS), contribute to immune activation. Increasing evidence indicates that T lymphocyte homeostasis disruptions are associated with immune activation. However, the mechanism by which LPS affects disruption of immune response is still not fully understood. Chronically SHIVB'WHU-infected Chinese rhesus macaques received 50 μg/kg body weight LPS in this study. LPS administration affected the virus/host equilibrium by elevating the levels of viral replication and activating T lymphocytes. LPS induced upregulation of CD8+ naïve T cells and downregulated the number of CD4+ and CD8+ T effector memory cells. The downregulated effector memory cells are associated with a lower frequency of monofunctional and polyfunctional cells, and an upregulated programmed cell death-1 (PD-1) expression on CD4+ and CD8+ T cells was observed in monkeys after LPS stimulation. Our data provide new insights into the function of LPS in the immune activation in SHIV/HIV infection.
影响因子：
3.7
作者：
Xia HJ;Ma JP;Zhang GH;Han JB;Wang JH;Zheng YT
通讯作者：
Zheng YT