The ALS-FTD-Q
The ALS-FTD-Q
复制标题
ALS-FTD-Q
作者：
MD Joost Raaphorst;MD Emma Beeldman;PhD Ben Schmand;MSc Joris Berkhout;W. Linssen;PhD Leonard H. van den Berg;PhD Yolande A. Pijnenburg;P. H. F. Md;MD Janneke G. Weikamp;MSc H. Jurgen Schelhaas;P. J. M. Md;MD John C. van Swieten;PhD Marianne de Visser;PhD Rob J. de Haan
目的：肌萎缩侧索硬化症（ALS）的行为障碍与额颞叶痴呆（ALS- bvftd）的行为变异重叠，因此评估其行为障碍具有重要意义。在目前使用的行为问卷中，运动症状和构音障碍没有被考虑在内。我们研究了一种新的ALS患者行为问卷（肌萎缩侧索硬化症-额颞叶痴呆问卷[ALS- ftd - q]）的临床计量学特性。方法：除了其他临床指标外，我们还对ALS- ftd - q的信度、临床效度和结构效度进行了检验，数据来自ALS-bvFTD （n = 103）、ALS-bvFTD （n = 10）、bvFTD （n = 25）、肌肉疾病对照组（n = 39）和对照组（n = 31）。采用额叶系统行为量表（FrSBe）、额叶行为量表（FBI）、医院焦虑和抑郁量表、ALS功能评定量表-修订版、额叶评估组、简易精神状态检查和流畅度指数来评估ALS- ftd - q的结构效度。此外，根据ALS-FTD-Q与FrSBe和FBI所得的行为障碍点患病率进行比较。结果：ALS-FTD-Q内部一致性好（Cronbach α = 0.92）。ALS-FTD-Q显示结构效度，因为它与其他行为测量高度相关（r = 0.80和0.79），与额叶功能和整体认知功能测量中度相关（r = 0.37; r = 0.32），与焦虑/抑郁和运动障碍不太相关（r = 0.18）。ALS- ftd - q区分ALS- bvftd患者、ALS患者和对照组。ALS- ftd - q测量的ALS患者行为障碍的点患病率低于FrSBe和FBI。结论：ALS- ftd - q是一种可行的、经临床验证的ALS行为障碍筛查工具。
Objective: The assessment of behavioral disturbances in amyotrophic lateral sclerosis (ALS) is important because of the overlap with the behavioral variant of frontotemporal dementia (ALS-bvFTD). Motor symptoms and dysarthria are not taken into account in currently used behavioral questionnaires. We examined the clinimetric properties of a new behavioral questionnaire for patients with ALS (Amyotrophic Lateral Sclerosis-Frontotemporal Dementia-Questionnaire [ALS-FTD-Q]). Methods: In addition to other clinimetric properties, we examined reliability, clinical validity, and construct validity of the ALS-FTD-Q, using data from patients with ALS (n = 103), ALS-bvFTD (n = 10), bvFTD (n = 25), muscle disease control subjects (n = 39), and control subjects (n = 31). Construct validity of the ALS-FTD-Q was assessed using the Frontal Systems Behavior scale (FrSBe), Frontal Behavioral Inventory (FBI), Hospital Anxiety and Depression Scale, ALS Functional Rating Scale−Revised, Frontal Assessment Battery, Mini-Mental State Examination, and a fluency index. In addition, the point prevalence of behavioral disturbances according to the ALS-FTD-Q was compared with those obtained with the FrSBe and FBI. Results: The internal consistency of the ALS-FTD-Q was good (Cronbach α = 0.92). The ALS-FTD-Q showed construct validity because it correlated highly with other behavioral measures (r = 0.80 and 0.79), moderately with measures of frontal functions and global cognitive functioning (r = 0.37; r = 0.32), and poorly with anxiety/depression and motor impairment (r = 0.18 for both). The ALS-FTD-Q discriminated between patients with ALS-bvFTD, patients with ALS, and control subjects. The point prevalence of behavioral disturbances in patients with ALS measured with the ALS-FTD-Q was lower than that for the FrSBe and FBI. Conclusion: The ALS-FTD-Q is a feasible and clinimetrically validated instrument for the screening of behavioral disturbances in ALS.
影响因子：
9.9
作者：
R. Faber
通讯作者：
R. Faber
影响因子：
--
作者：
Murphy, Jennifer M.;Henry, Roland G.;Lomen-Hoerth, Catherine
通讯作者：
Lomen-Hoerth, Catherine