Antiobesity effects of Kaempferia parviflora in spontaneously obese type II diabetic mice
Antiobesity effects of Kaempferia parviflora in spontaneously obese type II diabetic mice
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DOI：
10.1007/s11418-010-0461-2
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发表时间：
2011-01-01
影响因子：
3.3
通讯作者：
Aburada, Masaki
中科院分区：
文献类型：
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作者：
Akase, Tomoko;Shimada, Tsutomu;Aburada, Masaki
小花山茶花艾贝克(ex Baker，KP)在老挝和泰国被用作民间药物，用于降低血糖水平，改善血流，增强活力。本研究采用多因素遗传性疾病动物模型铃木肥胖(TSumura，Suzuki，ObeseDM，TSOD)小鼠(一种类似于人类代谢综合征的多因素遗传病动物模型)和相应的对照小鼠(TSumura，Suzuki，Non-肥胖(TSNO)小鼠)，研究了KP对肥胖及其下游症状(各种代谢紊乱)的预防作用。给TSOD和TSNO小鼠随机给予含KP(1%或3%)的饲料8周后，TSOD小鼠体重增加、内脏脂肪堆积、脂代谢异常、高胰岛素血症、糖耐量异常、胰岛素抵抗、高血压和周围神经病变均受到抑制，而TSNO小鼠则无明显差异。由于KP仅对肥胖动物具有包括减肥在内的代谢性疾病的预防作用，因此我们认为KP作为一种药物或食品成分在替代保健中将具有极其重要的价值。
Kaempferia parviflora Wall. Ex Baker (KP) has been used as a folk medicine in Laos and Thailand to lower blood glucose levels, improve blood flow, and increase vitality. This study investigated the preventive effects of KP on obesity and its downstream symptoms (various metabolic disorders) using Tsumura, Suzuki, Obese Diabetes (TSOD) mice, a multifactorial genetic disease animal model in which metabolic diseases develop spontaneously, similar to metabolic syndrome in humans, and Tsumura, Suzuki, Non-Obesity (TSNO) mice as the corresponding control mice. When feed that was mixed with KP (1 or 3%) was given ad libitum to TSOD and TSNO mice for 8 weeks, body weight increase, visceral fat accumulation, lipid metabolism abnormalities, hyperinsulinemia, glucose intolerance, insulin resistance, hypertension, and peripheral neuropathy were suppressed in TSOD mice, but no marked differences were observed in TSNO mice. Because KP had preventive effects on metabolic diseases, including antiobesity effects, only in obese animals, we propose that KP will be extremely valuable as a medicine or component of food in alternative health care.