Parts list for a microtubule depolymerising kinesin.
Parts list for a microtubule depolymerising kinesin.
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DOI：
10.1042/bst20180350
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发表时间：
2018-12-17
影响因子：
3.9
通讯作者：
Welburn JP
中科院分区：
文献类型：
--
作者：
Friel CT;Welburn JP
驱动蛋白超家族是一大类分子马达，它们利用ATP的周转来调节它们与微管细胞骨架的相互作用。这些马达以各种方式利用核苷酸周转和微管结合之间的耦合关系，使它们能够执行各种细胞功能。驱动蛋白-13家族是一组专门的微管解聚马达。这个家族的成员利用其微管不稳定活性来调节染色体分离、纤毛维持和神经元发育等过程。在这里，我们描述了目前的理解，这个家庭的驱动蛋白的结构和这些蛋白质的不同部分发挥的作用，在其微管解聚活性和更广泛的功能，这个家庭的驱动蛋白。
The Kinesin superfamily is a large group of molecular motors that use the turnover of ATP to regulate their interaction with the microtubule cytoskeleton. The coupled relationship between nucleotide turnover and microtubule binding is harnessed in various ways by these motors allowing them to carry out a variety of cellular functions. The Kinesin-13 family is a group of specialist microtubule depolymerising motors. Members of this family use their microtubule destabilising activity to regulate processes such as chromosome segregation, maintenance of cilia and neuronal development. Here, we describe the current understanding of the structure of this family of kinesins and the role different parts of these proteins play in their microtubule depolymerisation activity and in the wider function of this family of kinesins.